Transcriptional Regulation of Apolipoprotein A5 Gene Expression by the Nuclear Receptor ROR alpha
Journal Article
·
· Arteriosclerosis, Thrombosis, and Vascular Biology
OSTI ID:841115
- LBNL Library
Apolipoprotein A5 has recently been identified as a crucial determinant of plasma triglyceride levels. Our results showed that RORa up-regulates human APOA5 but has no effect on mouse apoa5 promoter. These data suggest an additional important physiological role for RORa in the regulation of genes involved in plasma triglyceride homeostasis in human and probably in the development of atherosclerosis
- Research Organization:
- Ernest Orlando Lawrence Berkeley National Laboratory, Berkeley, CA (US)
- Sponsoring Organization:
- USDOE. Office of Management Budget and Evaluation; National Institutes of Health Contract RHL071954A; Leducq Foundation (US)
- OSTI ID:
- 841115
- Report Number(s):
- LBNL--57328
- Journal Information:
- Arteriosclerosis, Thrombosis, and Vascular Biology, Journal Name: Arteriosclerosis, Thrombosis, and Vascular Biology Vol. 25
- Country of Publication:
- United States
- Language:
- English
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