Analysis of apolipoprotein A5, C3 and plasma triglyceride concentrations in genetically engineered mice
Journal Article
·
· Arteriosclerosis, Thrombosis, and Vascular Biology
- LBNL Library
To address the relationship between the apolipoprotein A5 and C3 genes, we generated independent lines of mice that either over-expressed or completely lacked both genes. We report both lines display normal triglyceride concentrations compared to over-expression or deletion of either gene alone. Together, these data support that APOA5 and APOC3 independently influence plasma triglyceride concentrations but in an opposing manner.
- Research Organization:
- Ernest Orlando Lawrence Berkeley National Laboratory, Berkeley, CA (US)
- Sponsoring Organization:
- US Department of Energy; National Institutes of Health National Heart Lung and Blood Institute Grants HL66681 and HL071954A,American Heart Association Postdoctoral Fellowship (US)
- DOE Contract Number:
- AC03-76SF00098
- OSTI ID:
- 838068
- Report Number(s):
- LBNL--55257
- Journal Information:
- Arteriosclerosis, Thrombosis, and Vascular Biology, Journal Name: Arteriosclerosis, Thrombosis, and Vascular Biology Journal Issue: 7 Vol. 24
- Country of Publication:
- United States
- Language:
- English
Similar Records
Independent effects of apolipoprotein AV and apolipoprotein CIII on plasma triglyceride concentrations
Apolipoprotein A5: A newly identified gene impacting plasmatriglyceride levels in humans and mice
Two independent apolipoprotein a5 Haplotypes influence human plasma triglyceride levels
Journal Article
·
Fri Aug 15 00:00:00 EDT 2003
· Arteriosclerosis, Thrombosis & Vascular Biology
·
OSTI ID:834631
Apolipoprotein A5: A newly identified gene impacting plasmatriglyceride levels in humans and mice
Journal Article
·
Sun Sep 15 00:00:00 EDT 2002
· Arteriosclerosis, Thrombosis and Vascular Biology(ATVB)
·
OSTI ID:894967
Two independent apolipoprotein a5 Haplotypes influence human plasma triglyceride levels
Journal Article
·
Mon Sep 16 00:00:00 EDT 2002
· Human Molecular Genetics
·
OSTI ID:822955