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Title: Philips 3T Intera Magnetic Resonance Imaging System and Upgrade of existing MRI equipment

Abstract

The objective of this proposal was twofold. First, upgrade existing MRI equipment, specifically a research 4.1T whole-body system. Second, purchase a clinical, state-of-the-art 3T MRI system tailored specifically to cardiovascular and neurological applications. This project was within the guidelines of ''Medical Applications and Measurement Science''. The goals were: [1] to develop beneficial applications of magnetic resonance imaging; [2] discover new applications of MR strategies for medical research; and [2] apply them for clinical diagnosis. Much of this proposal searched for breakthroughs in this noninvasive and nondestructive imaging technology. Finally, this proposal's activities focused on research in the basic science of chemistry, biochemistry, physics, and engineering as applied to bioengineering. The centerpiece of this grant was our 4.1T ultra-high field whole-body nuclear magnetic resonance system and the newly acquired state-of-the-art, heart and head dedicated 3T clinical MRI system. We have successfully upgraded the equipment for the 4.1T system so that it is now state-of-the-art with new gradient and radio frequency amplifiers. We also purchase a unique In Vivo EKG monitoring unit that will permit tracking clinical quality EKG signals while the patient is in a high field MR scanner. Important upgrades of a peripheral vascular coil and a state-of-the-art clinical workstationmore » for processing complex heart images were implemented. The most recent acquisition was the purchase of a state-of-the-art Philips 3T Intera clinical MRI system. This system is unique in that the magnet is only 5 1/2 feet long compare to over 12 feet long magnet of our 4.1T MRI system. The 3T MRI system is fully functional and its use and applications are already greatly benefiting the UAB with 200-300 micron resolution brain images and diagnostic quality MR angiography of coronary arteries in less than 5 minutes.« less

Authors:
Publication Date:
Research Org.:
University of Alabama at Birmingham (US)
Sponsoring Org.:
(US)
OSTI Identifier:
834766
Report Number(s):
DOE/ER/63118
TRN: US200507%%424
DOE Contract Number:
FG02-01ER63118
Resource Type:
Technical Report
Resource Relation:
Other Information: PBD: 14 May 2004
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; AMPLIFIERS; ARTERIES; BIOMEDICAL RADIOGRAPHY; BLOOD VESSELS; BRAIN; IN VIVO; NUCLEAR MAGNETIC RESONANCE; PATIENTS; RESOLUTION; MANGETIC RESONANCE IMAGING; HIGH-FIELD; 3T; 4.1T; 1.5T; UPGRADE

Citation Formats

Evanochko, William T. Philips 3T Intera Magnetic Resonance Imaging System and Upgrade of existing MRI equipment. United States: N. p., 2004. Web. doi:10.2172/834766.
Evanochko, William T. Philips 3T Intera Magnetic Resonance Imaging System and Upgrade of existing MRI equipment. United States. doi:10.2172/834766.
Evanochko, William T. Fri . "Philips 3T Intera Magnetic Resonance Imaging System and Upgrade of existing MRI equipment". United States. doi:10.2172/834766. https://www.osti.gov/servlets/purl/834766.
@article{osti_834766,
title = {Philips 3T Intera Magnetic Resonance Imaging System and Upgrade of existing MRI equipment},
author = {Evanochko, William T},
abstractNote = {The objective of this proposal was twofold. First, upgrade existing MRI equipment, specifically a research 4.1T whole-body system. Second, purchase a clinical, state-of-the-art 3T MRI system tailored specifically to cardiovascular and neurological applications. This project was within the guidelines of ''Medical Applications and Measurement Science''. The goals were: [1] to develop beneficial applications of magnetic resonance imaging; [2] discover new applications of MR strategies for medical research; and [2] apply them for clinical diagnosis. Much of this proposal searched for breakthroughs in this noninvasive and nondestructive imaging technology. Finally, this proposal's activities focused on research in the basic science of chemistry, biochemistry, physics, and engineering as applied to bioengineering. The centerpiece of this grant was our 4.1T ultra-high field whole-body nuclear magnetic resonance system and the newly acquired state-of-the-art, heart and head dedicated 3T clinical MRI system. We have successfully upgraded the equipment for the 4.1T system so that it is now state-of-the-art with new gradient and radio frequency amplifiers. We also purchase a unique In Vivo EKG monitoring unit that will permit tracking clinical quality EKG signals while the patient is in a high field MR scanner. Important upgrades of a peripheral vascular coil and a state-of-the-art clinical workstation for processing complex heart images were implemented. The most recent acquisition was the purchase of a state-of-the-art Philips 3T Intera clinical MRI system. This system is unique in that the magnet is only 5 1/2 feet long compare to over 12 feet long magnet of our 4.1T MRI system. The 3T MRI system is fully functional and its use and applications are already greatly benefiting the UAB with 200-300 micron resolution brain images and diagnostic quality MR angiography of coronary arteries in less than 5 minutes.},
doi = {10.2172/834766},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Fri May 14 00:00:00 EDT 2004},
month = {Fri May 14 00:00:00 EDT 2004}
}

Technical Report:

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  • During magnetic resonance imaging (MRI) procedures, a subject is exposed to three novel environmental stimuli which have drawn attention over the past decade as potential health hazards: (1) a relatively intense static magnetic field; (2) a time-varying magnetic field, and (3) a radiofrequency (RF) field. Thermoregulation is one of many physiological systems that can be affected by MRI, specifically by the RF radiation absorbed by the subject during MRI. While there is some sparse, albeit controversial data on the possible effects of static magnetic fields on thermoregulation, the major concern regarding potential health hazards of the MRI-induced thermal effects centersmore » on the RF radiation absorbed by a subject during a scan. The purpose of the paper is to review the studies that have impacted on understanding the thermoregulatory effects of MRI with special emphasis on the problems of selecting appropriate animal models for assessing the potential risk of RF radiation exposure during MRI.« less
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  • The role of Zn/Cu nutrition in oxygen free radical defense was investigate. Although endogenous free radical generation is increased in Zn and Cu deficiency, the free radical defense system in the lung and liver of Zn or Cu deficient rats was not compromised. The key oxygen radical defense enzyme, CuZn-superoxide dismutase (CuZnSOD) activity was directly related to tissue Cu and inversely related to tissue Zn concentrations. When oxidative stress (85% oxygen exposure for 7 days) was superimposed on Zn or Cu deficiency, Cu but not Zn deficient rats were able to increase lung CuZnSOD activity. The changes in lung CuZnSODmore » activity during oxidative stress were not correlated with lung Cu or Zn concentrations. In a pioneering application of proton MRI, lung damage was monitored in vivo and non-invasively to evaluate the overall capacity of the free radical defense system for protection against oxidative stress. Zn deficient rats displayed the most severe lung damage by MRI. Repletion of Zn in the diet prevented MRI-detectable hyperoxia-induced lung damage. Volume selective spectroscopy (VOSY) verified lung damage was due to an increased water content. Inability of Zn deficient rats to increase lung CuZnSOD activity appears to contribute to the severe free radical-induced lung damage.« less