NMR studies of isotopically labeled RNA

Conference · Thu Dec 01 00:00:00 EST 1994

OSTI ID:83382

Pardi, A ^[1]

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1. Univ. of Colorado, Boulder, CO (United States)

In summary, the ability to generate NMR quantities of {sup 15}N and {sup 13}C-labeled RNAs has led to the development of heteronuclear multi-dimensional NMR techniques for simplifying the resonance assignment and structure determination of RNAs. These methods for synthesizing isotopically labeled RNAs are only several years old, and thus there are still relatively few applications of heteronuclear multi-dimensional NMR techniques to RNA. However, given the critical role that RNAs play in cellular function, one can expect to see an increasing number of NMR structural studies of biologically active RNAs.

• Research Organization: Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
• OSTI ID: 83382
• Report Number(s): LA-12893-C; CONF-9403228-; ON: DE95012795; TRN: 95:004732-0013
• Resource Relation: Conference: Stable isotope applications in biomolecular structure and mechanisms, Santa Fe, NM (United States), 27-31 Mar 1994; Other Information: PBD: Dec 1994; Related Information: Is Part Of Stable isotope applications in biomolecular structure and mechanisms. A meeting to bring together producers and users of stable-isotope-labeled compounds to assess current and future needs; Trewhella, J.; Cross, T.A.; Unkefer, C.J. [eds.]; PB: 382 p.
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
40 CHEMISTRY
RNA
NMR IMAGING
MOLECULAR STRUCTURE
ISOTOPE APPLICATIONS
NUCLEAR MAGNETIC RESONANCE
LABELLING
NITROGEN 15
CARBON 13