skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Linking Molecular Events to Cellular Responses at Low Dose Exposures

Abstract

The studies proposed in this project are to define thresholds in cell signaling pathways that are required for cellular transformation and may be targeted by low-dose radiation. Defining thresholds in transformation-related signal transduction pathways that are sensitive to low-dose radiation would be an important advancement in risk assessment and could be used to demonstrate nonlinear relationships between low-dose radiation and cancer.

Authors:
; ;
Publication Date:
Research Org.:
Pacific Northwest National Lab., Richland, WA; National Cancer Institute, Frederick, MD (US)
Sponsoring Org.:
USDOE Office of Environmental Management (EM) (US)
OSTI Identifier:
833477
Report Number(s):
EMSP-69941-2000
R&D Project: EMSP 69941; TRN: US200430%%1525
Resource Type:
Technical Report
Resource Relation:
Other Information: PBD: 1 Jun 2000
Country of Publication:
United States
Language:
English
Subject:
54 ENVIRONMENTAL SCIENCES; 63 RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; NEOPLASMS; RADIATIONS; RISK ASSESSMENT; TRANSFORMATIONS

Citation Formats

Weber, Thomas J, Colburn, Nancy H, and Bowman, Michael K. Linking Molecular Events to Cellular Responses at Low Dose Exposures. United States: N. p., 2000. Web. doi:10.2172/833477.
Weber, Thomas J, Colburn, Nancy H, & Bowman, Michael K. Linking Molecular Events to Cellular Responses at Low Dose Exposures. United States. doi:10.2172/833477.
Weber, Thomas J, Colburn, Nancy H, and Bowman, Michael K. Thu . "Linking Molecular Events to Cellular Responses at Low Dose Exposures". United States. doi:10.2172/833477. https://www.osti.gov/servlets/purl/833477.
@article{osti_833477,
title = {Linking Molecular Events to Cellular Responses at Low Dose Exposures},
author = {Weber, Thomas J and Colburn, Nancy H and Bowman, Michael K},
abstractNote = {The studies proposed in this project are to define thresholds in cell signaling pathways that are required for cellular transformation and may be targeted by low-dose radiation. Defining thresholds in transformation-related signal transduction pathways that are sensitive to low-dose radiation would be an important advancement in risk assessment and could be used to demonstrate nonlinear relationships between low-dose radiation and cancer.},
doi = {10.2172/833477},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2000},
month = {6}
}

Technical Report:

Save / Share: