Linking Molecular Events to Cellular Responses at Low Dose Exposures
The studies proposed in this project are to define thresholds in cell signaling pathways that are required for cellular transformation and may be targeted by low-dose radiation. Defining thresholds in transformation-related signal transduction pathways that are sensitive to low-dose radiation would be an important advancement in risk assessment and could be used to demonstrate nonlinear relationships between low-dose radiation and cancer.
- Research Organization:
- Pacific Northwest National Lab., Richland, WA; National Cancer Institute, Frederick, MD (US)
- Sponsoring Organization:
- USDOE Office of Environmental Management (EM) (US)
- OSTI ID:
- 833477
- Report Number(s):
- EMSP-69941-2000; R&D Project: EMSP 69941; TRN: US200430%%1525
- Resource Relation:
- Other Information: PBD: 1 Jun 2000
- Country of Publication:
- United States
- Language:
- English
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