Bioavailability of Organic Solvents in soils: Input into Biologically Based Dose-Response Models for Human Risk Assessments
The purpose of this study was to develop methods to expose rats and humans percutaneously and to use PBPK modeling to assess the percutaneous permeability of volatile compounds from aqueous or soil exposures. To estimate dermal absorption under realistic environmental exposure conditions, a patch system was developed that allowed for the volatilization of the compounds from the soil without contamination of inhaled or exhaled breath. The end product for this research will be a tested framework for the rapid screening of real and potential exposures while simultaneously developing physiologically based pharmacokinetic (PBPK) models to comprehensively evaluate and compare exposures to volatile chemicals from either contaminated soil or water.
- Research Organization:
- University of California at San Francisco, San Francisco, California (US)
- Sponsoring Organization:
- USDOE Office of Environmental Management (EM) (US)
- DOE Contract Number:
- FG07-97ER62509
- OSTI ID:
- 828375
- Report Number(s):
- EMSP-59282--1999
- Country of Publication:
- United States
- Language:
- English
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Bioavailability of Organic Solvents in Soils: Input into Biologically-Based Dose- Response Models for Human Risk Assessments
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