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Title: Mechanisms of Enhanced Cell Killing at Low Doses: Implications for Radiation Risk

Abstract

We have shown that cell lethality actually measured after exposure to low-doses of low-LET radiation, is markedly enhanced relative to the cell lethality previously expected by extrapolation of the high-dose cell-killing response. Net cancer risk is a balance between cell transformation and cell kill and such enhanced lethality may more than compensate for transformation at low radiation doses over a least the first 10 cGy of low-LET exposure. This would lead to a non-linear, threshold, dose-risk relationship. Therefore our data imply the possibility that the adverse effects of small radiation doses (<10 cGy) could be overestimated in specific cases. It is now important to research the mechanisms underlying the phenomenon of low-dose hypersensitivity to cell killing, in order to determine whether this can be generalized to safely allow an increase in radiation exposure limits. This would have major cost-reduction implications for the whole EM program.

Authors:
;
Publication Date:
Research Org.:
Gray Cancer Institute (US)
Sponsoring Org.:
(US)
OSTI Identifier:
816335
Report Number(s):
DOE/ER/62878
EMSP 69981; TRN: US0304966
DOE Contract Number:  
FG07-99ER62878
Resource Type:
Technical Report
Resource Relation:
Other Information: PBD: 15 Oct 2003
Country of Publication:
United States
Language:
English
Subject:
61 RADIATION PROTECTION AND DOSIMETRY; CELL KILLING; CELL TRANSFORMATIONS; EXTRAPOLATION; NEOPLASMS; RADIATION DOSES; DOSE-RESPONSE RELATIONSHIPS; LOW DOSE IRRADIATION; MAXIMUM PERMISSIBLE EXPOSURE; LIMITING VALUES

Citation Formats

Dr. Peter J. Johnston, and Dr. George D. Wilson. Mechanisms of Enhanced Cell Killing at Low Doses: Implications for Radiation Risk. United States: N. p., 2003. Web. doi:10.2172/816335.
Dr. Peter J. Johnston, & Dr. George D. Wilson. Mechanisms of Enhanced Cell Killing at Low Doses: Implications for Radiation Risk. United States. doi:10.2172/816335.
Dr. Peter J. Johnston, and Dr. George D. Wilson. Wed . "Mechanisms of Enhanced Cell Killing at Low Doses: Implications for Radiation Risk". United States. doi:10.2172/816335. https://www.osti.gov/servlets/purl/816335.
@article{osti_816335,
title = {Mechanisms of Enhanced Cell Killing at Low Doses: Implications for Radiation Risk},
author = {Dr. Peter J. Johnston and Dr. George D. Wilson},
abstractNote = {We have shown that cell lethality actually measured after exposure to low-doses of low-LET radiation, is markedly enhanced relative to the cell lethality previously expected by extrapolation of the high-dose cell-killing response. Net cancer risk is a balance between cell transformation and cell kill and such enhanced lethality may more than compensate for transformation at low radiation doses over a least the first 10 cGy of low-LET exposure. This would lead to a non-linear, threshold, dose-risk relationship. Therefore our data imply the possibility that the adverse effects of small radiation doses (<10 cGy) could be overestimated in specific cases. It is now important to research the mechanisms underlying the phenomenon of low-dose hypersensitivity to cell killing, in order to determine whether this can be generalized to safely allow an increase in radiation exposure limits. This would have major cost-reduction implications for the whole EM program.},
doi = {10.2172/816335},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2003},
month = {10}
}