Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Therapeutic approaches to superantigen-based diseases: a review

Journal Article · · JMR. Journal of Molecular Recognition
DOI:https://doi.org/10.1002/jmr.612· OSTI ID:811068
;
Superantigens secreted by the bacterial pathogen Staphyloccocus aureus are extremely potent toxins that overstimulate the host immune system by binding to the MHC class II and T cell receptors and activating a large population of T cells. Superantigen infection has been shown to be the causative agents in acute diseases, food poisoning and toxic shock syndrome, and in more chronic conditions such as inflammatory skin diseases. In addition to the toll on public health, S. aureus superantigens also represent a potential biothreat to our national security. To address these risks, a number of different therapeutic strategies have been developed that target different aspects of the pathogenic mechanism of S. aureus and superantigen infection. These therapies, which encompass strategies as diverse as production of neutralizing antibodies, inhibitory peptide/receptor design and blockage of superantigen gene transcription, are being tested for treatment of established S. aureus infections in pre- and post-exposure scenarios. In this review, we will describe these different strategies and their efficacies in inhibition of superantigen-induced effects in the host, and present the future outlook for successfully producing therapies for superantigen-based disease
Research Organization:
Los Alamos National Laboratory (LANL), Los Alamos, NM
Sponsoring Organization:
USDOE
DOE Contract Number:
W-7405-ENG-36
OSTI ID:
811068
Report Number(s):
LA-UR-02-5763
Journal Information:
JMR. Journal of Molecular Recognition, Journal Name: JMR. Journal of Molecular Recognition Journal Issue: 2 Vol. 16; ISSN 0952-3499
Country of Publication:
United States
Language:
English

References (61)

Kinetics of IL-2 and interferon-γ production, expression of IL-2 receptors, and cell proliferation in human mononuclear cells exposed to staphylococcal enterotoxin A journal November 1985
Blockade of T Lymphocyte Costimulation with Cytotoxic T Lymphocyte–Associated Antigen 4–Immunoglobulin (Ctla4ig) Reverses the Cellular Pathology of Psoriatic Plaques, Including the Activation of Keratinocytes, Dendritic Cells, and Endothelial Cells journal September 2000
T cell-mediated lethal shock triggered in mice by the superantigen staphylococcal enterotoxin B: critical role of tumor necrosis factor journal January 1992
Superantigen antagonist protects against lethal shock and defines a new domain for T-cell activation journal April 2000
Divergence of Human and Nonhuman Primate Lymphocyte Responses to Bacterial Superantigens journal September 1995
Superantigen implicated in dependence of HIV-1 replication in T cells on TCR V β expression journal July 1992
Inhibition of Bacterial Superantigens by Peptides and Antibodies journal February 2001
High-affinity binding of staphylococcal enterotoxins A and B to HLA-DR journal May 1989
Protection against Bacterial Superantigen Staphylococcal Enterotoxin B by Passive Vaccination journal May 2002
High affinity T cell receptors from yeast display libraries block T cell activation by superantigens11Edited by I. A. Wilson journal April 2001
Bacterial superantigens in human disease: structure, function and diversity journal December 1995
The staphylococcal enterotoxins and their relatives journal June 1990
CTLA-4: new insights into its biological function and use in tumor immunotherapy journal July 2002
Pirfenidone Blocks the In Vitro and In Vivo Effects of Staphylococcal Enterotoxin B journal June 2002
The Polyphenol Chlorogenic acid Inhibits Staphylococcal Exotoxin-Induced Inflammatory Cytokines and Chemokines journal January 2002
Structure-Based Design of a Bispecific Receptor Mimic That Inhibits T Cell Responses to a Superantigen journal April 2001
Autoinducer of Virulence As a Target for Vaccine and Therapy Against Staphylococcus aureus journal April 1998
Interaction of Staphylococcus aureus toxin "superantigens" with human T cells. journal November 1989
Prevention of diseases caused by Staphylococcus aureus using the peptide RIP journal September 2000
Triggering and exacerbation of autoimmune arthritis by themycoplasma arthritidis superantigen mam journal July 1993
Use of a Staphylococcus aureus Conjugate Vaccine in Patients Receiving Hemodialysis journal February 2002
Defining a novel domain of staphylococcal toxic shock syndrome toxin-1 critical for major histocompatibility complex class II binding, superantigenic activity, and lethality journal February 2000
Superantigen binding to a T cell receptor beta chain of known three- dimensional structure journal December 1995
The Vβ-specific superantigen staphylococcal enterotoxin B: Stimulation of mature T cells and clonal deletion in neonatal mice journal January 1989
RNAIII inhibiting peptide (RIP), a global inhibitor of Staphylococcus aureus pathogenesis: structure and function analysis journal October 2001
Staphylococcal and Streptococcal Pyrogenic Toxins Involved in Toxic Shock Syndrome and Related Illnesses journal January 1990
Intravenous immunoglobulin contains specific antibodies inhibitory to activation of T cells by staphylococcal toxin superantigens [see comment] journal February 1993
The toxicity of staphylococcal enterotoxin B in mice is mediated by T cells journal February 1990
Regulation of Staphylococcus aureus Pathogenesis via Target of RNAIII-activating Protein (TRAP) journal October 2000
T-cell antigen receptor binding sites for the microbial superantigen staphylococcal enterotoxin A. journal August 1992
Superantigen Vaccines: A Comparative Study of Genetically Attenuated Receptor-Binding Mutants of Staphylococcal Enterotoxin A journal August 1996
An overview of nosocomial infections, including the role of the microbiology laboratory. journal October 1993
V beta-specific stimulation of human T cells by staphylococcal toxins journal May 1989
Induction of relapsing paralysis in experimental autoimmune encephalomyelitis by bacterial superantigen journal October 1993
Human Antibodies to Bacterial Superantigens and Their Ability To Inhibit T-Cell Activation and Lethality journal February 2001
The Disease Spectrum, Epidemiology, and Etiology of Toxic-Shock Syndrome journal October 1984
Staphylococcal enterotoxins can reactivate experimental allergic encephalomyelitis. journal September 1993
Interleukin-10 induces a long-term antigen-specific anergic state in human CD4+ T cells journal July 1996
Toxic-Shock Syndrome: Epidemiologic Features, Recurrence, Risk Factors, and Prevention journal December 1980
CTLA4Ig-mediated blockade of T-cell costimulation in patients with psoriasis vulgaris journal May 1999
Development of engineered vaccines effective against structurally related bacterial superantigens journal November 1998
Directed evolution of a stable scaffold for T-cell receptor engineering journal July 2000
Inhibition of Staphylococcal Enterotoxin B-Induced Lymphocyte Proliferation and Tumor Necrosis Factor Alpha Secretion by MAb5, an Anti-Toxic Shock Syndrome Toxin 1 Monoclonal Antibody journal June 2000
'Superbug' hurdles key drug barrier journal August 2002
Toxic shock syndrome toxin-1 complexed with a class II major histocompatibility molecule HLA-DR1 journal December 1994
Evidence for a clonal origin of methicillin resistance in Staphylococcus aureus journal January 1993
Agonist Properties of a Microbial Superantigen Peptide journal June 1993
RNAIII inhibiting peptide (RIP) inhibits agr-regulated toxin production journal October 2001
Mucosal Tolerance to a Bacterial Superantigen Indicates a Novel Pathway To Prevent Toxic Shock journal May 2002
CTLA-4 is a second receptor for the B cell activation antigen B7. journal September 1991
Three-dimensional structure of a human class II histocompatibility molecule complexed with superantigen journal April 1994
Superantigens – powerful modifiers of the immune system journal March 2000
A Mutational Analysis of the Binding of Staphylococcal Enterotoxins B and C3 to the T Cell Receptor β Chain and Major Histocompatibility Complex Class II journal March 1998
Microbial superantigens: from structure to function journal August 2000
Immunotherapy against antibiotic-resistant bacteria: the Russian experience with an antistaphylococcal hyperimmune plasmaand immunoglobulin journal September 2000
Crystal structure of a T-cell receptor β-chain complexed with a superantigen journal November 1996
Inhibition of Toxic Shock Syndrome Toxin-I-Induced Cytokine Production and T Cell Activation by Interleukin-IO, Interleukin-4, and Dexamethasone journal October 1995
Costimulatory B7 Molecules in the Pathogenesis of Infectious and Autoimmune Diseases journal October 1996
Binding of a soluble alpha beta T-cell receptor to superantigen/major histocompatibility complex ligands. journal August 1994
Protective effects of niacinamide in staphylococcal enterotoxin-B-induced toxicity journal January 1996
Autocrine regulation of toxin synthesis by Staphylococcus aureus. journal February 1995

Similar Records

Structure-based receptor MIMICS targeted against bacterial superantigen toxins
Patent · Tue Aug 18 00:00:00 EDT 2009 · OSTI ID:968328
Systems approach to characterizing cell signaling in host-pathogen response to staphylococcus toxin.
Conference · Mon Dec 31 23:00:00 EST 2001 · OSTI ID:976244
Crystal Structure of Staphylococcal Enterotoxin G (SEG) in Complex with a Mouse T-cell Receptor Beta Chain
Journal Article · Thu Jan 13 23:00:00 EST 2011 · Journal of Biological Chemistry · OSTI ID:1018669

Related Subjects

59 BASIC BIOLOGICAL SCIENCES