Response to issues and data submissions on the carcinogenicity of tetrachloroethylene (perchloroethylene)
Technical Report
·
OSTI ID:80574
The scientific debate over the potential carciongenicity of tetrachloroethylene (perchloroethylene, perc, PCE) spans several years. The document reviews the issues considered by the EPA`s Science Advisory Board (SAB) during its review of the Draft Addenedum to the Health Assessment Document for Tetrachloroethylene (1986) and discusses relevant research data published between 1986 and early 1991. The topics include three tumor end points observed in rodents: (1) hepatocellular carcinoma in male and female mice, (2) renal tubule neoplasia in male rats, and (3) mononuclear cell leukemia in male and female rats, and data on metabolism, metagenicity, peroxisome proliferation, and alpha-2u-globulin. EPA`s recommended weight-of-evidence classification of perc is B2, probable human carcinogen.
- Research Organization:
- Environmental Protection Agency, Washington, DC (United States). Office of Health and Environmental Assessment
- OSTI ID:
- 80574
- Report Number(s):
- PB--95-221958/XAB; EPA--600/6-91/002F
- Country of Publication:
- United States
- Language:
- English
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