Role of carboxylesterase in species variation of oxime protection against soman. (Reannouncement with new availability information). Open literature pub
Technical Report
·
OSTI ID:80536
Oxime protection against soman, a highly toxic anticholinesterase agent, was examined in mice and guinea pigs. The maximal protection produced by the oximes PAM and Hi-6 varied as much as 6-fold between these species. Since endogenous carboxylesterase (CaE) is known to be an important determinant of species variation in soman toxicity, the protection of PAM and HI-6 against soman was also measured in animals whose endogenous CaE was inhibited with cresylbenzodioxaphosphorin oxide.
- Research Organization:
- Army Medical Research Inst. of Chemical Defense, Aberdeen Proving Ground, MD (United States)
- OSTI ID:
- 80536
- Report Number(s):
- AD-A--234355/6/XAB; USAMRICD-P--90-030
- Country of Publication:
- United States
- Language:
- English
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