Oxime-induced reactivation of acetylcholinesterase inhibited by organophosphinates. (Reannouncement with new availability information)
Technical Report
·
OSTI ID:80534
The comparative potency of oximes for reactivation of inhibited eel acetylcholinesterase (AChE) in vitro is dependent on the organophosphinate inhibitor. Some of the data, dealing with a reference organophosphonate, support the conclusion of other investigators that the oxime potency order is also dependent on the inhibiting phosphonate. This work was done to identify more clearly the nature of phosphinylated AChE with regard to oxime reactivation potency and the potential of phosphinates as pretreatment drugs to protect AChE against organophosphonate poisoning.
- Research Organization:
- Army Medical Research Inst. of Chemical Defense, Aberdeen Proving Ground, MD (United States)
- OSTI ID:
- 80534
- Report Number(s):
- AD-A--232968/8/XAB; USAMRICD-P--88-022
- Country of Publication:
- United States
- Language:
- English
Similar Records
Oxime-induced reactivation of carboxylesterase inhibited by organophosphorus compounds
Oxime-induced reactivation of carboxylesterase inhibited by organophosphorus compounds
Acetylcholinesterase inhibition and anti-Soman efficacy of homologs of physostigmine. (Reannouncement with new availability information)
Technical Report
·
Thu May 13 00:00:00 EDT 1993
·
OSTI ID:7234914
Oxime-induced reactivation of carboxylesterase inhibited by organophosphorus compounds
Technical Report
·
Wed Jun 01 00:00:00 EDT 1994
·
OSTI ID:220283
Acetylcholinesterase inhibition and anti-Soman efficacy of homologs of physostigmine. (Reannouncement with new availability information)
Technical Report
·
Wed Dec 30 23:00:00 EST 1992
·
OSTI ID:189781