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Adjoint Monte Carlo Methods for Radiation Therapy Treatment Planning

Conference ·
OSTI ID:786142
; ;
Intensity-modulated radiation therapy is a new technique for administering external beam radiation therapy. This technology modulates the intensity and shape of the treatment beam as a function of source position and patient anatomy. This process of conforming the source to the patient requires the optimization of the independent variables of the source field. In this study, adjoint Monte Carlo methods were used to compute the sensitivity field that corresponds to a prescribed dose distribution. Given these data, linear and nonlinear optimization models were constructed with a simplified geometry to compute an optimized set of beams to deliver a desired dose distribution. It was shown that, for a simple geometric model, adjoint Monte Carlo methods can be used as the basis for inverse radiation therapy treatment planning. By using flux-to-dose conversion factors as adjoint sources, it is possible to develop an influence matrix that provides the sensitivity of the dose at a single point in the patient to all points in the treatment source field. These data may be used to determine an optimized set of treatment beams.
Research Organization:
University of Wisconsin, Madison, Wisconsin (US)
Sponsoring Organization:
US Department of Energy (US)
OSTI ID:
786142
Report Number(s):
NONE; ISSN 0003-018X; CODEN TANSAO; ISSN 0003-018X; CODEN TANSAO
Country of Publication:
United States
Language:
English

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Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ADJOINT DIFFERENCE METHOD
ANATOMY
MODULATION
MONTE CARLO METHOD
OPTIMIZATION
PATIENTS
PLANNING
RADIATION DOSE DISTRIBUTIONS
RADIOTHERAPY