It takes a tissue to make a tumor: Epigenetics, cancer and the microenvironment
How do normal tissues limit the development of cancer? This review discusses the evidence that normal cells effectively restrict malignant behavior, and that such tissue forces must be subjugated to establish a tumor. The action of ionizing radiation will be specifically discussed regarding the disruption of the microenvironment that promotes the transition from preneoplastic to neoplastic growth. Unlike the highly unpredictable nature of genetic mutations, the response of normal cells to radiation damage follows an epigenetic program similar to wound healing and other damage responses. Our hypothesis is that the persistent disruption of the microenvironment in irradiated tissue compromises its ability to suppress carcinogenesis.
- Research Organization:
- Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
- Sponsoring Organization:
- USDOE Director, Office of Science. Office of Biological and Environmental Research. Life Sciences Division (US)
- DOE Contract Number:
- AC03-76SF00098
- OSTI ID:
- 782518
- Report Number(s):
- LBNL-47303; R&D Project: 804D01; TRN: US200201%%653
- Journal Information:
- Journal of Mammary Gland Biology and Neoplasia, Vol. 6, Issue 2; Other Information: Journal Publication Date: 2001; PBD: 19 Jan 2001
- Country of Publication:
- United States
- Language:
- English
Similar Records
Recent progress in defining mechanisms and potential targets for prevention of normal tissue injury after radiation therapy
The not-so innocent bystander: The microenvironment as a therapeutic target in cancer