Synthesis of high specific activity [ethyl-1,2-3H]-labeled chlorpyrifos oxon and diazoxon

Journal Article · Mon May 01 00:00:00 EDT 2000 · Journal of Labelled Compounds and Radiopharmaceuticals

DOI:https://doi.org/10.1002/1099-1344(200011)43:13<1275::AID-JLCR416>3.3.CO;2-7· OSTI ID:779735

Zhang, Nanjing ^[1]; Morimoto, Hiromi; Williams, Philip G; Casida, John E

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1. LBNL Library

[Ethyl-1,2-3H] Chlorpyrifos oxon and [ethyl-1,2-3H] diazoxon were synthesized at a specific activity of 79 and 58 Ci/mmol, respectively, by catalytic tritiation of the corresponding monovinyl analogs over Pd/C. Direct evidence is provided that the high specific activity results from isotope exchange of the terminal vinylic protons prior to saturation of the double bond. This radiosynthesis procedure is applicable to the toxicologically-important oxon metabolites of many commercial O-O-diethyl phosphorothioate pesticides.

• Research Organization: Lawrence Berkeley National Lab., CA (US)
• Sponsoring Organization: National Institutes of Health (US)
• DOE Contract Number: AC03-76SF00098
• OSTI ID: 779735
• Report Number(s): LBNL--45857
• Journal Information: Journal of Labelled Compounds and Radiopharmaceuticals, Journal Name: Journal of Labelled Compounds and Radiopharmaceuticals Journal Issue: 13 Vol. 43; ISSN 0362-4803; ISSN JLCRD4
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
ACETYLCHOLINESTERASE CHLORPYRIFOS OXON DIAZOXON INSECTICIDE TRITIUM ISOTOPE EXCHANGE
CHEMICAL PREPARATION
DIAZO COMPOUNDS
ISOTOPIC EXCHANGE
LABELLED COMPOUNDS
METABOLITES
ORGANIC CHLORINE COMPOUNDS
PESTICIDES
TRITIUM