A novel variant of DR4 (DRB1*0421) identified in a patient with polychondritis

Journal Article · Wed Jan 11 04:00:00 EST 1995 · Immunogenetics

DOI:https://doi.org/10.1007/BF00182335· OSTI ID:75615

Keller, E; Yao, Z; Volgger, A; Albert, E D ^[1]; Lang, B ^[2]

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1. Univ. of Munich, Muechen (Germany)
2. Univ. of Regensburg Medical Center (Germany)

Class II major histocompatibility complex (MHC) molecules bind peptides and present them to helper T lymphocytes as the initial step of an immune response. The specificity of peptide binding by class II molecules is determined by amino acid exchanges in the hypervariable regions. There are groups of HLA-DRB1 gene alleles, which differ from each other from members of another group by as many as 10-15 amino acid exchanges. The largest such group is DRB1*04, of which there are at present 20 different alleles known. In the process of HLA-DRB1*04 subtyping of patients with polychondritis, which is associated with DR4, we identified one patient (SMH), whose DNA displayed a novel pattern of oligonucleotide reactivity. The oligonucleotide typing results suggested one or more nucleotide differences in the region encoding amino acid 37 of the DRB1*0301 allele. 7 refs., 1 fig.

• Sponsoring Organization: USDOE
• OSTI ID: 75615
• Journal Information: Immunogenetics, Journal Name: Immunogenetics Journal Issue: 2-3 Vol. 41; ISSN 0093-7711; ISSN IMNGBK
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
AMINO ACID SEQUENCE
DNA SEQUENCING
GENES
HISTOCOMPATIBILITY COMPLEX
IMMUNE SYSTEM DISEASES
OLIGONUCLEOTIDES
PATIENTS
PEPTIDES
POLYMERASE CHAIN REACTION