The BALB.B6-Cmv1{sup r} mouse: A strain congenic for Cmv1 and the NK gene complex

Journal Article · Tue Jan 10 23:00:00 EST 1995 · Immunogenetics

OSTI ID:75611

Scalzo, A A; Lyons, P A; Fitzgerald, N A; Forbes, C A; Shellam, G A ^[1]

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1. Univ. of Western Australia, Nedlands (Australia)

Genetically determined resistance to murine cytomegalovirus (MCMV) in mice is controlled by both H2 and non-H2 genes. We have identified a phenotypically-defined, autosomal dominant, non-H2 gene, designated Cmvl, that regulates MCMV replication in the spleens of inbred mice. C57BL/6J mice possess the Cmvl{sup r} and exhibit low titers of MCMV replication, whereas the BALB/c strain, which possesses the Cmvl{sup s} allele, exhibits high virus titers in the spleen. 19 refs., 4 figs.

• OSTI ID: 75611
• Journal Information: Immunogenetics, Journal Name: Immunogenetics Journal Issue: 2-3 Vol. 41; ISSN 0093-7711; ISSN IMNGBK
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
ANIMAL BREEDING
BIOLOGICAL MARKERS
CHROMOSOMES
DNA REPLICATION
DOMINANT MUTATIONS
GENES
GENETIC MAPPING
NATURAL KILLER CELLS
PROBES
TRANSGENIC MICE
VIRUSES