The nucleotide sequence of the sheep MHC class II DNA gene
- Moredun Research Institute, Edinburgh (United Kingdom)
- Univ. of Edinburgh (United Kingdom)
The human MHC class II DNA gene was identified and sequenced by Trowsdale and Kelly. When a molecular map of the HLA-D region became available, it was shown that the HLA-DNA gene was unusual in not having a B gene partner situated within a few kilobases (kb), the nearest B gene being HLA-DPB1. The nearest unpaired B gene is HLA-DOB which is approximately 160 kb telomeric of HLA-DNA. More recently, the mouse MHC class II genes H-20A and H-20B were shown to be equivalent to the HLA-DNA and HLA-DOB genes. Moreover, the mouse genes expressed an MHC class II protein whose tissue distribution was restricted to B cells and epithelial cell of the thymic medulla. No corresponding HLA-DN protein has been reported. 21 refs., 3 figs.
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 75609
- Journal Information:
- Immunogenetics, Journal Name: Immunogenetics Journal Issue: 2-3 Vol. 41; ISSN 0093-7711; ISSN IMNGBK
- Country of Publication:
- United States
- Language:
- English
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