Assessment of intrarenal perfusion with radioxenon: a critical review of analytical factors and their implications in man. [/sup 133/Xe, dogs, rats]

Journal Article · Thu Apr 01 04:00:00 EST 1976 · Semin. Nucl. Med.; (United States)

DOI:https://doi.org/10.1016/S0001-2998(76)80004-9· OSTI ID:7362365

Hollenberg, N K; Mangel, R; Fung, H Y.M.

Radioxenon has achieved wide use for assessing tissue perfusion. Its application to the kidney for assessing mean blood flow and intrarenal perfusion rates is reviewed. Correlation with alternative methods in animals suggests that the initial disappearance slope provides an adequate measure of mean renal blood flow despite the theoretical limitations of this approach. The stochastic method and compartmental analysis can also provide an acceptable measure of mean renal blood flow, but only after the slowest flow components have been removed. Compartmental analysis does, however, provide an index of cortical perfusion not available from other methods. The evidence that the rapid component of xenon washout provides an index of cortical perfusion in man is reviewed, along with insights gained from the application of this approach to human disease.

• Research Organization: Peter Bent Brigham Hospital, Boston
• OSTI ID: 7362365
• Journal Information: Semin. Nucl. Med.; (United States), Journal Name: Semin. Nucl. Med.; (United States) Vol. 6:2; ISSN SMNMA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD FLOW
BODY
DAYS LIVING RADIOISOTOPES
DOGS
EVEN-ODD NUCLEI
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
KIDNEYS
MAMMALS
MAN
MEASURING METHODS
NUCLEI
ORGANS
PERFUSED ORGANS
PRIMATES
RADIOISOTOPES
RATS
RODENTS
TRACER TECHNIQUES
VERTEBRATES
XENON 133
XENON ISOTOPES