Photolytic degradation of. cap alpha. -((dibutylamino)methyl)-6,8-dichloro-2-(3',4'-dichlorophenyl)-4-quinoline methanol: an experimental antimalarial. [UV radiation]
A study of the effects of various storage conditions on the rate and products of degradation of the quinoline methanol antimalarial agent, ..cap alpha..((dibutylamino)methyl)-6,8-dichloro-2-(3',4'-dichlorophenyl)-4-quinoline methanol, was undertaken. The degradation was followed by high-pressure liquid chromatography and TLC in oxygenated and deoxygenated methanol, ethanol, chloroform, and chloroform--heptane mixtures under uv and laboratory fluorescent lighting irradiation, as well as in the absence of light. The kinetics of degradation confirmed the major catalyzing factor to be uv irradiation. The compound was stable in the absence of light and reasonably stable under fluorescent lighting both in the presence and absence of oxygen. The degradation resulted in a major product, 6,8-dichloro-2-(3',4'-dichlorophenyl)-4-quinoline-carboxaldehyde, whose structure was confirmed by elemental analysis and IR, NMR, and mass spectral data.
- OSTI ID:
- 7360141
- Journal Information:
- J. Pharm. Sci.; (United States), Journal Name: J. Pharm. Sci.; (United States) Vol. 64:10; ISSN JPMSA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
400300 -- Organic Chemistry-- (-1987)
550600* -- Medicine
62 RADIOLOGY AND NUCLEAR MEDICINE
ALCOHOLS
CHEMICAL REACTIONS
DECOMPOSITION
DISEASES
DRUGS
ELECTROMAGNETIC RADIATION
HEMIC DISEASES
HYDROXY COMPOUNDS
INFECTIOUS DISEASES
MAGNETIC RESONANCE
MALARIA
MASS SPECTRA
METHANOL
NUCLEAR MAGNETIC RESONANCE
ORGANIC COMPOUNDS
PHOTOCHEMICAL REACTIONS
PHOTOLYSIS
RADIATION EFFECTS
RADIATIONS
RESONANCE
SPECTRA
THERAPY
ULTRAVIOLET RADIATION