Effect of S-2-(3-aminopropylamino)ethylphosphorothioic acid (WR-2721) on intestinal crypt survival. II. Fission neutrons. [Fission neutrons; mice]
Journal Article
·
· Radiat. Res.; (United States)
The effect of S-2-(3-aminopropylamino)ethylphosphorothioic acid (WR-2721) was tested in the intestine for its ability to protect against fission neutron irradiation. The parameters tested were lethality, intestinal crypt survival, and DNA synthesizing cellularity. The results showed a dose modification factor (DMF) of 1.6 for lethality in mice treated with WR-2721 prior to fission neutron irradiation. This resulted in the shifting of the dose--mortality probit curve to the right by 149 rad. The crypt survival curve in protected mice was found to have a slope which was significantly different from unprotected controls. The DMF calculated at 50 percent crypt survival was found to be 1.3. The dose-dependent DNA synthesizing cellularity in the intestine 3 days after irradiation was tested in protected and unprotected animals. WR-2721 was shown to protect the intestine from about 120 to 140 rad of fission neutrons. This resulted in a DMF between 1.4 and 1.5. (auth)
- Research Organization:
- Univ. of Louisville, KY
- OSTI ID:
- 7352674
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 65:3; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BARYONS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOSYNTHESIS
BODY
CRYPT CELLS
DIGESTIVE SYSTEM
DNA
DRUGS
ELEMENTARY PARTICLES
FERMIONS
FISSION NEUTRONS
GASTROINTESTINAL TRACT
HADRONS
INTESTINES
IRRADIATION
MAMMALS
MICE
NEUTRONS
NUCLEIC ACIDS
NUCLEONS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
RADIATION EFFECTS
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY EFFECTS
RESPONSE MODIFYING FACTORS
RODENTS
SOMATIC CELLS
SURVIVAL TIME
SYNTHESIS
THIOIC ACIDS
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BARYONS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOSYNTHESIS
BODY
CRYPT CELLS
DIGESTIVE SYSTEM
DNA
DRUGS
ELEMENTARY PARTICLES
FERMIONS
FISSION NEUTRONS
GASTROINTESTINAL TRACT
HADRONS
INTESTINES
IRRADIATION
MAMMALS
MICE
NEUTRONS
NUCLEIC ACIDS
NUCLEONS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
RADIATION EFFECTS
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY EFFECTS
RESPONSE MODIFYING FACTORS
RODENTS
SOMATIC CELLS
SURVIVAL TIME
SYNTHESIS
THIOIC ACIDS
VERTEBRATES