ESR of sulfur-substituted purines. 6-methylmercaptopurine at 300 K. [X Radiation]

Journal Article · Wed Sep 01 04:00:00 EDT 1976 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3574339· OSTI ID:7351083

Pugh, Jr, H L; Alexander, C Jr

Single crystals of the sulfur-containing DNA base analog 6-methylmercaptopurine have been prepared and irradiated by x rays. Electron spin resonance techniques have been used to study the radiation-induced radicals at room temperatures. Four radical species (I to IV) were observed to be stable at room temprature. None of these radicals showed resolvable hyperfine structure, but three had large g-value variations about average values of I, 2.026; II, 2.012; and III, 2.0078. These three radical species are attributed to ..pi..-electron monosulfide radicals formed by rupture of the S--CH/sub 3/ bond. Radical species IV is believed to be a hydrocarbon-centered radical with very little spin density on hydrogen or nitrogen atoms. These results indicate that the formation of the hydrogen-addition radical on the purine ring, found in other irradiated purines at 300 K, may be hindered by sulfur substituents in purines.

• Research Organization: Univ. of Alabama, University
• OSTI ID: 7351083
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 67:3; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560111* -- Radiation Effects on Biochemicals-- In Vitro-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANTIMETABOLITES
ANTIMITOTIC DRUGS
CHEMICAL RADIATION EFFECTS
CHEMISTRY
DRUGS
ELECTROMAGNETIC RADIATION
ELECTRON SPIN RESONANCE
ELEMENTS
HETEROCYCLIC COMPOUNDS
IONIZING RADIATIONS
MAGNETIC RESONANCE
MERCAPTOPURINE
MOLECULAR STRUCTURE
NONMETALS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
PURINES
RADIATION CHEMISTRY
RADIATION EFFECTS
RADIATIONS
RADICALS
RESONANCE
SULFUR
THIOLS
X RADIATION