Respiratory and intraperitoneal infection of mice with encephalomyocarditis virus: effect of sublethal x-irradiation on host resistance and survival
The relationships governing host resistance to viral infection were evaluated in mice following respiratory or peritoneal infection with three strains of encephalomyocarditis (EMC) virus, which were antigenically similar but differed in virulence. Host resistance to each strain was evaluated by determining the mean lethal dose LD50, and the mean infectious dose ID50. The contribution of non-specific resistance to the overall defense of the host was assessed in mice that had received 450 R of x irradiation prior to viral infection. Experimental results indicate that host capacity to resist respiratory infection exceeds that for peritoneal infection for the three EMC strains. It is concluded that respiratory inoculation of virus affords better immunization against EMC virus infection than does peritoneal infection. (Author) (GRA)
- Research Organization:
- Rijksverdedigingsorganisatie TNO, Rijswijk (Netherlands). Medisch Biologisch Lab. TNO
- OSTI ID:
- 7339129
- Report Number(s):
- N-75-24331; MBL-1975-2; TDCK-65777
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
DISEASES
ELECTROMAGNETIC RADIATION
ENCEPHALITIS
IMMUNITY
INFECTIOUS DISEASES
IONIZING RADIATIONS
IRRADIATION
MAMMALS
MICE
MICROORGANISMS
NERVOUS SYSTEM DISEASES
PARASITES
RADIATION EFFECTS
RADIATIONS
RESPIRATORY SYSTEM DISEASES
RODENTS
SUBLETHAL IRRADIATION
SURVIVAL TIME
VERTEBRATES
VIRUSES
X RADIATION