Divalent cation ionophore A23187: a potent protein synthesis inhibitor. [Antibiotic drug]

Technical Report ·

OSTI ID:7338305

Bottenstein, J E; de Vellis, J

The antibiotic drugs A23187 is a potent protein synthesis inhibitor at very low concentrations. This may be a direct effect on protein synthesis or may result from release of internal stores of divalent cations. In addition, the ionophore apparently increases leucine and decreases uridine transport into the cells. Therefore, in some experimental conditions using intact cells, the effects of A23187 may not be solely attributable to increased permeability of plasma membranes to divalent cations.

• Research Organization: California Univ., Los Angeles (USA). Lab. of Nuclear Medicine and Radiation Biology
• DOE Contract Number: E(04-1)-GEN-12
• OSTI ID: 7338305
• Report Number(s): UCLA-12-1096
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
ANTIBIOTICS
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
CELL MEMBRANES
PERMEABILITY
PROTEINS
BIOSYNTHESIS
ANIMAL CELLS
CATIONS
CELL CONSTITUENTS
CHARGED PARTICLES
DRUGS
IONS
KINETICS
MEMBRANES
ORGANIC COMPOUNDS
REACTION KINETICS
SYNTHESIS
550200* - Biochemistry
551000 - Physiological Systems