Tolerance induction and transplantation of the mouse heart

Journal Article · Mon Jan 01 04:00:00 EST 1973 · Surg. Forum; (United States)

OSTI ID:7327797

Jirsch, D W; Kraft, N; Diener, E

Long-surviving cardiac allografts can be produced by repopulating irradiated mice with steam cell rich fractions of syngeneic mouse spleen but not bone marrow. Short-term discontinuous HAMTS treatment of irradiated allografted mice can also render mice specifically tolerant. Spleen cells from animals tolerant to cardiac allografts remain reactive to alloantigens in vitro. Lymph node cells from tolerant mice are immunosuppressive and transfer tolerance when injected with whole bone marrow into secondary irradiated, allografted recipients.

• Research Organization: Univ. of Alberta, Edmonton
• OSTI ID: 7327797
• Journal Information: Surg. Forum; (United States), Journal Name: Surg. Forum; (United States) Vol. 24; ISSN SUFOA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BONE MARROW
CARDIOVASCULAR SYSTEM
HEART
HEMATOPOIETIC SYSTEM
IMMUNE REACTIONS
MAMMALS
MICE
ORGANS
RADIATION EFFECTS
RODENTS
SPLEEN
TISSUES
TRANSPLANTS
VERTEBRATES