Inhibition of human lymphocyte transformation by human. cap alpha. -fetoprotein (HAFP); HAFP monomers and multimers and a resistant lymphocyte subpopulation
Journal Article
·
· J. Immunol.; (United States)
OSTI ID:7316513
We have previously shown that human ..cap alpha..-fetoprotein (HAFP) inhibits the response in vitro of human lymphocytes to a variety of mitogenic stimuli. In this report we present evidence that HAFP preparations containing dimeric and trimeric forms are no more inhibitory than HAFP monomeric isolates. HAFP isolates of low inhibitory potency cannot impede the capacity of high-potency HAFP to inhibit lymphocyte transformation. Since lymphocyte responses to phytomitogens or anti-human thymocyte antiserum cannot be totally suppressed by increasing doses of HAFP, we conclude that human lymphocyte preparations contain a population of lymphocytes resistant to the inhibitory action of HAFP.
- Research Organization:
- Univ. of Chicago
- OSTI ID:
- 7316513
- Journal Information:
- J. Immunol.; (United States), Journal Name: J. Immunol.; (United States) Vol. 119:2; ISSN JOIMA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Human alpha-fetoprotein as a modulator of human lymphocyte transformation: correlation of biological potency with electrophoretic variants
Inhibition of human lymphocyte transformation by human. cap alpha. -fetoprotein (HAFP): studies on the mode of HAFP action and the role of HAFP polymorphism
Demonstration of the inhibitory effect of human alpha-fetoprotein on in vitro transformation of human lymphocytes
Journal Article
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Tue Nov 30 23:00:00 EST 1976
· Proc. Natl. Acad. Sci. U.S.A.; (United States)
·
OSTI ID:7227757
Inhibition of human lymphocyte transformation by human. cap alpha. -fetoprotein (HAFP): studies on the mode of HAFP action and the role of HAFP polymorphism
Conference
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Fri Dec 31 23:00:00 EST 1976
·
OSTI ID:7291187
Demonstration of the inhibitory effect of human alpha-fetoprotein on in vitro transformation of human lymphocytes
Journal Article
·
Sun Aug 01 00:00:00 EDT 1976
· Proc. Natl. Acad. Sci. U.S.A.; (United States)
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OSTI ID:7156187
Related Subjects
550200 -- Biochemistry
550300* -- Cytology
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
IMMUNE SERUMS
IN VITRO
INHIBITION
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MAN
ORGANIC COMPOUNDS
POPULATIONS
PRIMATES
PROTEINS
SOMATIC CELLS
VERTEBRATES
550300* -- Cytology
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
IMMUNE SERUMS
IN VITRO
INHIBITION
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MAN
ORGANIC COMPOUNDS
POPULATIONS
PRIMATES
PROTEINS
SOMATIC CELLS
VERTEBRATES