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Recovery of irradiated bone marrow cells in carbon-treated mice. [X radiation]

Journal Article · · Radiat. Res.; (United States)
DOI:https://doi.org/10.2307/3574523· OSTI ID:7314542
;
The recovery of bone marrow cells irradiated in vitro and transplanted into reticuloendothelial system (RES)-blockaded host mice was studied. Mice treated with carbon particles provided a favorable environmental effect on the recovery of irradiated spleen colony-forming cells. The shift of the survival curve of colony-forming units (CFU/sub s/) in the carbon-treated mice was not due to an increase in the extrapolation number but to an apparent decrease in radiation sensitivity of the cells. The average weight of the spleen colony at Day 10 did not exhibit any significant difference between experimental and control mice. The split-dose experiment revealed that there was no significant additional acceleration of the stem cell recovery although recovery of CFU/sub s/ was extensively enhanced by transplantation into the carbon-treated animals. From these results it is suggested that RES-blockaded mice provide a favorable microenvironment for the recovery of hemopoietic stem cells after irradiation.
Research Organization:
Kyoto Univ.
OSTI ID:
7314542
Journal Information:
Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 69:1; ISSN RAREA
Country of Publication:
United States
Language:
English

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Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BODY
BONE MARROW CELLS
CARBON
CFU
CONNECTIVE TISSUE CELLS
ELECTROMAGNETIC RADIATION
ELEMENTS
FRACTIONATED IRRADIATION
IONIZING RADIATIONS
IRRADIATION
MAMMALS
MICE
NONMETALS
ORGANS
PARTICLES
RADIATION EFFECTS
RADIATIONS
RECOVERY
RETICULOENDOTHELIAL SYSTEM
RODENTS
SOMATIC CELLS
SPLEEN
STEM CELLS
SURVIVAL CURVES
TISSUES
VERTEBRATES
X RADIATION