One hundred patients with acute leukemia treated by chemotherapy, total body irradiation, and allogeneic marrow transplantation. [Gamma radiation]

Journal Article · Fri Apr 01 00:00:00 EST 1977 · Blood; (United States)

OSTI ID:7313364

Thomas, E D; Buckner, C D; Banaji, M

One hundred patients, 54 with acute myelogenous leukemia (AML) and 46 with acute lymphoblastic leukemia (ALL), considered to be in the end stages of their disease, after combination chemotherapy were treated by marrow transplantation. All patients were given a marrow graft from an HLA-identical sibling after receiving 1000-rad total body irradiation (TBI). One group of 43 patients was given cyclophosphamide (CY), 60 mg/kg on each of 2 days, 5 and 4 days before TBI. In a second group of 31 patients, additional chemotherapy was given before CY and TBI. In a third group of 19 patients, BCNU was given before CY and TBI. A fourth group of 7 patients received other chemotherapy regimens before TBI. Six patients died 3 to 17 days after marrow infusion without evidence of engraftment. Ninety-four patients were engrafted rejected and only one patient rejected the graft. Thirteen patients are alive with a marrow graft, on no maintenance antileukemic therapy, and without recurrent leukemia 1--4/sup 1///sub 2/ yr after transplantation. Three have chronic graft-versus-host disease (GVHD). The relapse rate appeared to be relatively constant over the first 2 yr and was extremely low after that time. Neither survival nor leukemic relapse appeared to be influenced by the type of leukemia nor by the preparative chemotherapy regimen given before TBI. Patients in fair clinical condition at the time of transplantation showed significantly longer survival times than patients in poor condition (p = 0.001). This observation, coupled with the observation that some patients may be cured of their disease, indicates that marrow transplantation should now be undertaken earlier in the management of patients with acute leukemia who have an HLA-matched sibling marrow donor.

• Research Organization: Fred Hutchinson Cancer Research Center, Seattle
• OSTI ID: 7313364
• Journal Information: Blood; (United States), Vol. 49:4
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BONE MARROW
TRANSPLANTS
LEUKEMIA
CHEMOTHERAPY
RADIOTHERAPY
PATIENTS
BIOLOGICAL RADIATION EFFECTS
GRAFT-HOST REACTION
GAMMA RADIATION
BIOLOGICAL EFFECTS
BODY
DISEASES
ELECTROMAGNETIC RADIATION
HEMATOPOIETIC SYSTEM
HEMIC DISEASES
IONIZING RADIATIONS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
RADIATION EFFECTS
RADIATIONS
RADIOLOGY
THERAPY
TISSUES
560151* - Radiation Effects on Animals- Man