Partial deletion of long arm of chromosome 17

Journal Article · Thu Jul 01 00:00:00 EDT 1976 · Arch. Intern. Med.; (United States)

DOI:https://doi.org/10.1001/archinte.136.7.825· OSTI ID:7294602

Golomb, H M ^[1]; Rowley, J; Vardiman, J; Baron, J; Locker, G; Krasnow, S

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1. Univ. of Chicago, IL

Two patients with acute promyelocytic leukemia had an identical chromosomal abnormality detected by fluorescence banding. In each case, the clinical course was rapidly fatal, and was characterized by a lack of response to chemotherapy with cytarabine and thioguanine, and was complicated by disseminated intravascular coagulation. Bone marrow cells from each patient contained 46 chromosomes; in each instance, however, one chromosome 17 had a deletion of almost one half of the proximal portion of the long arm (del(17)(q11q21 or 22)).

• OSTI ID: 7294602
• Journal Information: Arch. Intern. Med.; (United States), Vol. 136
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
BONE MARROW CELLS
CHROMOSOMAL ABERRATIONS
CHEMOTHERAPY
BIOLOGICAL EFFECTS
DRUGS
LEUKEMIA
CHROMOSOMES
FLUORESCENCE
PATIENTS
STRAND BREAKS
ANIMAL CELLS
CONNECTIVE TISSUE CELLS
DISEASES
HEMIC DISEASES
LUMINESCENCE
MUTATIONS
NEOPLASMS
SOMATIC CELLS
THERAPY
550300* - Cytology