Glucose turnover in kelp bass (Paralabrax sp. ): in vivo studies with (6-/sup 3/H,6-/sup 14/C)glucose
(6-/sup 3/H,6-/sup 14/C)glucose was injected via an indwelling arterial cannula in free-swimming, fed, and fasted kelp bass to determine hepatic glucose production, peripheral glucose uptake, minimal glucose mass, mean transit time, and the percent of carbon recycling under the two different nutritional states. Mean plasma glucose levels remained unchanged in fed and fasted fish (48 +- 8 vs. 43 +- 8 mg/100 ml). During steady-state conditions, glucose replacement rates of fed and fasted fish determined with (6-/sup 3/H)glucose are similar (0.035 +- 0.006 vs. 0.025 +- 0.003 mg/min per 100 g) and do not differ from rates determined with (6-/sup 14/C)glucose (0.035 +- 0.005 vs. 0.026 +- 0.002). The minimal glucose masses and the mean transit times determined with both isotopes are also similar suggesting that plasma glucose levels and glucose turnover are maintained in fish fasted up to 40 days with no apparent increase in carbon recycling. Nonsteady-state isotope experiments suggest that these fish can alter rates of hepatic glucose production and peripheral uptake in response to hyper- and hypoglycemia.
- Research Organization:
- Univ. of Southern California, Los Angeles
- OSTI ID:
- 7291153
- Journal Information:
- Am. J. Physiol.; (United States), Vol. 1:1
- Country of Publication:
- United States
- Language:
- English
Similar Records
Glucose tracer, kinetics and turnover in monkeys and chickens infused with ethanol, 1,3-butanediol, or fructose
Glucose turnover, oxidation, and indices of recycling in severely traumatized patients
Related Subjects
FISHES
METABOLISM
GLUCOSE
ARTERIES
BLOOD PLASMA
CARBON
CARBON 14
FASTING
FEEDING
HYPERGLYCEMIA
IN VIVO
INJECTION
ISOTOPES
LIVER
MASS
RECYCLING
SYNTHESIS
TRITIUM
UPTAKE
ALDEHYDES
ANIMALS
AQUATIC ORGANISMS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD VESSELS
BODY
BODY FLUIDS
CARBOHYDRATES
CARBON ISOTOPES
CARDIOVASCULAR SYSTEM
DIGESTIVE SYSTEM
ELEMENTS
EVEN-EVEN NUCLEI
GLANDS
HEXOSES
HYDROGEN ISOTOPES
INTAKE
LIGHT NUCLEI
MONOSACCHARIDES
NONMETALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPES
SACCHARIDES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
550501* - Metabolism- Tracer Techniques