Dose-response relationships for postirradiation erythrocyte levels. [Gamma radiation, beagles]

Thesis/Dissertation · Thu Jan 01 04:00:00 EST 1976

OSTI ID:7291040

Bainter, H T

The responses of the circulating erythrocyte levels in beagles, as measured by the hematocrits, following exposures to /sup 60/Co radiations were studied. Quantitative dose-response relationships were determined on a short-term basis following acute exposures to male adult beagles. Quantitative dose-response relationships were determined on a long-term basis following acute exposures to male and female beagles in utero at 8 days postcoitus (dpc), 28 dpc and 55 dpc, and to male and female beagles at 2 days postpartum (dpp), 70 dpp and 365 dpp. For the short-term responses, the response was quantified by two different methods. One method used the average deviation of the postirradiation hematocrit from the preirradiation value as a response. The response of average deviation was shown to be dose dependent and the dose-response relationship was shown to be modified as a result of previous irradiations. The other method involved describing the time dependent change in the postirradiation hematocrit with two nonlinear mathematical models. The estimated parameters of the nonlinear model that best described the time dependent change were then treated as response variables. Linear model analysis techniques were used to investigate and demonstrate the existence of quantitative dose-response relationships for these estimated parameters. The estimated parameters were also shown to be dependent on previous irradiation. In the case of the long-term responses, linear models were formulated to account for variation due to sex, age, month of observation and calendar year of observation. Statistically significant dose-response relationships were shown to exist at one year of age for male beagles irradiated at 55 dpc and for female beagles irradiated at 8 dpc and 70 dpp. Statistically significant dose-response relationships were shown to exist at two years of age for male beagles irradiated at 55 dpc, 2 ddp and 365 dpp, and for female beagles irradiated at 365 dpp.

• OSTI ID: 7291040
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABUNDANCE
ANIMALS
BEAGLES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY FLUIDS
DOGS
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
ERYTHROCYTES
GAMMA RADIATION
IONIZING RADIATIONS
IRRADIATION
MAMMALS
MATHEMATICS
PRENATAL IRRADIATION
RADIATION EFFECTS
RADIATIONS
STATISTICS
VERTEBRATES