Increasing incidence of hypothyroidism within one year after radioiodine therapy for toxic diffuse goiter. [/sup 131/I]

Journal Article · Wed Feb 01 00:00:00 EST 1978 · J. Nucl. Med.; (United States)

OSTI ID:7286913

Von Hofe, S E; Dorfman, S G; Carrette, R F; Young, R L

Patients treated with 10 mCi of I-131 for toxic diffuse goiter in the period January 1974--June 1976 were evaluated for development of hypothyroidism. Fifty percent were hypothyroid within 3 months and 69 percent within 1 year of treatment. Our data suggest that there is a higher incidence of hypothyroidism after standard doses of I-131 in the 1970s as contrasted with treatment groups in the 1950s and 1960s. The pathophysiology of this increased incidence is not known with certainty; however, infrequent use of thionamide medication, together with recent increases in dietary iodine, may render the gland more radiosensitive.

• Research Organization: Wilford Hall USAF Medical Center (AFSC), Lackland AFB, TX
• OSTI ID: 7286913
• Journal Information: J. Nucl. Med.; (United States), Vol. 19:2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
GOITER
RADIOTHERAPY
HYPOTHYROIDISM
RADIOINDUCTION
SIDE EFFECTS
THYROID
RADIOSENSITIVITY
IODINE 131
PATIENTS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
DAYS LIVING RADIOISOTOPES
DISEASES
ENDOCRINE DISEASES
ENDOCRINE GLANDS
GLANDS
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
MEDICINE
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPES
RADIOLOGY
THERAPY
560161* - Radionuclide Effects
Kinetics
& Toxicology- Man