Determination of free thyroxine in serum by radioimmunoassay. [/sup 125/I and /sup 131/I tracer techniques]

Journal Article · Thu Sep 01 00:00:00 EDT 1977 · Clin. Chem.; (United States)

OSTI ID:7285220

Jiang, N S; Tue, K A

We describe a sensitive and specific radioimmunoassay for free thyroxine, directly determined in the diffusate obtained from equilibrium dialysis of serum. The intra- and interassay precisions were 7.5 +- 0.27 and 9.1 +- 0.58 ng/liter (mean +- SD), respectively. The free thyroxine concentrations of normal persons and patients with thyroid disease were as follows: normal, 7.6 +- 1.7; euthyroid patients recieving phenythoin, 6.9 +- 1.4; hypothyroidism, 2.9 +- 1.3; and hyperthyroidism, 32.3 +- 12.3 ng/liter (mean +- SD).

• Research Organization: Mayo Clinic and Mayo Foundation, Rochester, MN
• OSTI ID: 7285220
• Journal Information: Clin. Chem.; (United States), Journal Name: Clin. Chem.; (United States) Vol. 23:9; ISSN CLCHA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINO ACIDS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD SERUM
BODY
CARBOXYLIC ACIDS
CHEMICAL ANALYSIS
DAYS LIVING RADIOISOTOPES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
ENDOCRINE DISEASES
ENDOCRINE GLANDS
GLANDS
HORMONES
HYPERTHYROIDISM
HYPOTHYROIDISM
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE 131
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC IODINE COMPOUNDS
ORGANS
PATIENTS
PEPTIDE HORMONES
RADIOASSAY
RADIOIMMUNOASSAY
RADIOISOTOPES
THYROID
THYROID HORMONES
THYROIDITIS
THYROXINE
TRACER TECHNIQUES