Determination of thyroxine-binding globulin in human serum by single radial immunodiffusion and radioimmunoassay. [/sup 125/I tracer technique]

Journal Article · Thu Sep 01 04:00:00 EDT 1977 · Clin. Chem.; (United States)

OSTI ID:7285219

Kagedal, B; Kallberg, M

Two immunochemical methods for determination of thyroxine-binding globulin in human serum were developed, in which the purified globulin and monospecific antiserum to it are used. One method, based on radial immunodiffusion, has good precision and values for analytical recovery. Reference values obtained for men were 9.8 to 17.8 mg/liter and for women 11.3 to 20.5 mg/liter. The sex-related difference was significant. The other method is based on radioimmunoassay, with use of an iodinated acylating agent for the labeling of thyroxine-binding globulin. The relative merits of the two methods are discussed.

• Research Organization: University Hospital, Linkoeping, Sweden
• OSTI ID: 7285219
• Journal Information: Clin. Chem.; (United States), Journal Name: Clin. Chem.; (United States) Vol. 23:9; ISSN CLCHA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINO ACIDS
BETA DECAY RADIOISOTOPES
BINDING ENERGY
CARBOXYLIC ACIDS
DAYS LIVING RADIOISOTOPES
DIFFUSION
ELECTRON CAPTURE RADIOISOTOPES
ENERGY
GLOBULINS
HORMONES
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC IODINE COMPOUNDS
PEPTIDE HORMONES
PROTEINS
RADIOASSAY
RADIOIMMUNOASSAY
RADIOISOTOPES
THYROID HORMONES
THYROXINE
TRACER TECHNIQUES