Cutaneous effects of topical indomethacin, an inhibitor of prostaglandin synthesis, on uv-damaged skin
Journal Article
·
· J. Invest. Dermatol.; (United States)
Topical application of a 2.5 percent indomethacin (IM) solution to the sunburned skin of humans and guinea pigs resulted in a marked decrease in ultraviolet light (UVL)-induced erythema. In humans, a decrease in skin temperature and hyperalgesia to near normal levels was also observed. Epidermal responses to UVL injury such as keratinocyte cell death and altered DNA synthesis proceeded unmodified by IM. Repeated applications of IM in the 48-hr period following UVL exposure did not improve upon the results obtained following a single treatment. Guinea-pig skin provides a relevant model system for evaluating the effects of topical nonsteroidal anti-inflammatory agents on sunburn. (auth)
- Research Organization:
- Univ. of Miami, FL
- OSTI ID:
- 7282506
- Journal Information:
- J. Invest. Dermatol.; (United States), Journal Name: J. Invest. Dermatol.; (United States) Vol. 64:5; ISSN JIDEA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Effect of topical indomethacin on uvr-induced redness and prostaglandin E levels in sunburned guinea pig skin
Reduction of erythema in hairless guinea pigs after cutaneous sulfur mustard vapor exposure by pretreatment with niacinamide, promethazine and indomethacin
Prolonged ultraviolet light-induced erythema and the cutaneous carcinoma phenotype
Journal Article
·
Wed Mar 31 23:00:00 EST 1976
· Prostaglandins; (United States)
·
OSTI ID:5371670
Reduction of erythema in hairless guinea pigs after cutaneous sulfur mustard vapor exposure by pretreatment with niacinamide, promethazine and indomethacin
Technical Report
·
Sat Dec 30 23:00:00 EST 1995
·
OSTI ID:220277
Prolonged ultraviolet light-induced erythema and the cutaneous carcinoma phenotype
Journal Article
·
Fri Oct 01 00:00:00 EDT 1976
· J. Invest. Dermatol.; (United States)
·
OSTI ID:7226209
Related Subjects
560151* -- Radiation Effects on Animals-- Man
560152 -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
DRUGS
ELECTROMAGNETIC RADIATION
ERYTHEMA
GUINEA PIGS
IRRADIATION
MAMMALS
MAN
ORGANS
PRIMATES
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOSENSITIVITY EFFECTS
RODENTS
SKIN
SYMPTOMS
ULTRAVIOLET RADIATION
VERTEBRATES
560152 -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
DRUGS
ELECTROMAGNETIC RADIATION
ERYTHEMA
GUINEA PIGS
IRRADIATION
MAMMALS
MAN
ORGANS
PRIMATES
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOSENSITIVITY EFFECTS
RODENTS
SKIN
SYMPTOMS
ULTRAVIOLET RADIATION
VERTEBRATES