Proteins in growth regulation during early development. Progress report, 1976--1977

Technical Report · Mon Aug 01 04:00:00 EDT 1977

DOI:https://doi.org/10.2172/7282347· OSTI ID:7282347

Klein, N. W.

Studies were conducted to determine mechanisms regulating the synthesis of serum proteins by the yolk-sac and to determine if serum proteins are developmental signals. Synthesis of serum proteins in the yolk-sac and liver was determined at various stages of development and effects of teratogenic agents and genetic mutations on protein synthesis were studied. The regulation of serum protein synthesis was studied in cell cultures and in cell-free protein synthesizing systems derived from the yolk-sac. Studies were also conducted on effects of serum proteins on rat embryos, chick embryos without yolk-sacs, and isolated brains. (HLW)

• Research Organization: Connecticut Univ., Storrs (USA). Dept. of Animal Genetics
• DOE Contract Number: EY-76-S-02-3139
• OSTI ID: 7282347
• Report Number(s): COO-3139-29
• Country of Publication: United States
• Language: English

Related Subjects

550000* -- Biomedical Sciences
Basic Studies
550200 -- Biochemistry
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
BIOSYNTHESIS
BIRDS
BLOOD SERUM
BODY
BRAIN
CELL CULTURES
CENTRAL NERVOUS SYSTEM
CHICKENS
DIGESTIVE SYSTEM
DRUGS
EMBRYOS
FETAL MEMBRANES
FOWL
GLANDS
GROWTH
LIVER
MAMMALS
MEMBRANES
METABOLISM
MUTATIONS
NERVOUS SYSTEM
ONTOGENESIS
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RATS
RODENTS
SYNTHESIS
VERTEBRATES