Experimental induction of bone tumors by short-lived bone-seeking radionuclides
Single and repeated applications of /sup 224/Ra and single applications of /sup 227/Th to more than 600 female NMRI mice 3 to 4 weeks old, and to male NMRI mice have led to a high rate of osteosarcomas. Tumor incidence is dose-related. /sup 227/Th is more carcinogenic than /sup 224/Ra which induced the highest tumor incidence of 60 percent after a single injection of 5 ..mu..Ci per Kg body weight or more. Repeated injections of /sup 224/Ra to female mice yielded a tumor incidence of up to 92 percent. Most of these osteosarcomas consist of well-differentiated bone-forming osteoplastic tissue. Half of the tumors occurred in the spine, particularly in the lumbar region. In protraction experiments, multifocal osteosarcomas have been observed. Less than 10 percent of the mice with osteosarcoma had developed metastases in lung, spleen, liver, and kidney. The possible mechanisms of the protraction effect are discussed.
- OSTI ID:
- 7282067
- Journal Information:
- Recent Results Cancer Res.; (United States), Vol. 54
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
OSTEOSARCOMAS
RADIOINDUCTION
RADIUM 224
CARCINOGENESIS
SKELETON
BIOLOGICAL RADIATION EFFECTS
THORIUM 227
DOSE-RESPONSE RELATIONSHIPS
MICE
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALKALINE EARTH ISOTOPES
ALPHA DECAY RADIOISOTOPES
ANIMALS
BIOLOGICAL EFFECTS
BODY
DAYS LIVING RADIOISOTOPES
DISEASES
EVEN-EVEN NUCLEI
EVEN-ODD NUCLEI
HEAVY NUCLEI
ISOTOPES
MAMMALS
NEOPLASMS
NUCLEI
ORGANS
PATHOGENESIS
RADIATION EFFECTS
RADIOISOTOPES
RADIUM ISOTOPES
RODENTS
SARCOMAS
SKELETAL DISEASES
THORIUM ISOTOPES
VERTEBRATES
560162* - Radionuclide Effects
Kinetics
& Toxicology- Animals
Plants
Microorganisms
& Cells