Theoretical studies on Pro-Leu-Gly-NH/sub 2/ conformation
Journal Article
·
· Proc. Natl. Acad. Sci. U.S.A.; (United States)
Classical potential function calculations were carried out on the hypothalamic factor Pro-Leu-Gly-NH/sub 2/. The results indicate that the proposed 10-membered, hydrogen-bonded ..beta..-turn conformation of this tripeptide is a strongly preferred structure. Its stability appears to be inherent in the rather rigid backbone conformation of the leucine residue rather than the hydrogen bond between the carboxamide proton of glycinamide and the C bond O of the proline moiety; the glycinamide has little influence on the phi-psi of the leucine backbone structure. The type II ..beta..-turn structure of the Pro-Leu-Gly-NH/sub 2/ is preferred.
- Research Organization:
- Brookhaven National Lab., Upton, NY
- OSTI ID:
- 7273439
- Journal Information:
- Proc. Natl. Acad. Sci. U.S.A.; (United States), Journal Name: Proc. Natl. Acad. Sci. U.S.A.; (United States) Vol. 73:4; ISSN PNASA
- Country of Publication:
- United States
- Language:
- English
Similar Records
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Synthesis, conformational analysis, and biological activities of cyclic enkephalins and model cyclic peptides containing thioamides as amide bond replacements
Journal Article
·
Wed Sep 12 00:00:00 EDT 1979
· J. Am. Chem. Soc.; (United States)
·
OSTI ID:5825942
Crystal structure and conformation of the cyclic hexapeptide cyclo-(Gly-L-Pro-D-Ala)/sub 2/
Journal Article
·
Tue Feb 13 23:00:00 EST 1979
· J. Am. Chem. Soc.; (United States)
·
OSTI ID:6232737
Synthesis, conformational analysis, and biological activities of cyclic enkephalins and model cyclic peptides containing thioamides as amide bond replacements
Thesis/Dissertation
·
Thu Dec 31 23:00:00 EST 1987
·
OSTI ID:6948542
Related Subjects
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
400301* -- Organic Chemistry-- Chemical & Physicochemical Properties-- (-1987)
500200 -- Environment
Atmospheric-- Chemicals Monitoring & Transport-- (-1989)
54 ENVIRONMENTAL SCIENCES
AMINES
AMINO ACIDS
AZOLES
BODY
BOND ANGLE
BRAIN
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM
COHERENT SCATTERING
CONFORMAL MAPPING
CRYSTALLOGRAPHY
DIFFRACTION
GLYCINE
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HYPOTHALAMUS
LENNARD-JONES POTENTIAL
LEUCINE
NERVOUS SYSTEM
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PEPTIDES
PROLINE
PROTEINS
PYRROLES
PYRROLIDINES
SCATTERING
STRUCTURAL CHEMICAL ANALYSIS
TOPOLOGICAL MAPPING
TRANSFORMATIONS
X-RAY DIFFRACTION
400301* -- Organic Chemistry-- Chemical & Physicochemical Properties-- (-1987)
500200 -- Environment
Atmospheric-- Chemicals Monitoring & Transport-- (-1989)
54 ENVIRONMENTAL SCIENCES
AMINES
AMINO ACIDS
AZOLES
BODY
BOND ANGLE
BRAIN
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM
COHERENT SCATTERING
CONFORMAL MAPPING
CRYSTALLOGRAPHY
DIFFRACTION
GLYCINE
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HYPOTHALAMUS
LENNARD-JONES POTENTIAL
LEUCINE
NERVOUS SYSTEM
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PEPTIDES
PROLINE
PROTEINS
PYRROLES
PYRROLIDINES
SCATTERING
STRUCTURAL CHEMICAL ANALYSIS
TOPOLOGICAL MAPPING
TRANSFORMATIONS
X-RAY DIFFRACTION