Bioaccumulation, biotransformation and DNA binding of PAHs in feral eel (Anguilla anguilla) exposed to polluted sediments: A field survey

Journal Article · Wed Jun 01 00:00:00 EDT 1994 · Environmental Toxicology and Chemistry; (United States)

DOI:https://doi.org/10.1002/etc.5620130604· OSTI ID:7273339

Oost, R Van Der; Heida, H; Satumalay, K ^[1]; Schooten, F.J. Van ^[2]; Ariese, F; Vermeulen, N P.E. ^[3]

---

1. OMEGAM Environmental Research Inst., Amsterdam (Netherlands)
2. Univ. of Limburg, Maastricht (Netherlands). Dept. of Health Risk Analysis and Toxicology
3. Free Univ. of Amsterdam (Netherlands)

Samples of sediment and eel taken from six sites in Amsterdam with different levels of water pollution were analyzed for 16 parental PAHs. In addition, biliary PAH metabolites and hepatic PAH-DNA adducts were determined in the eel to evaluate biomonitoring techniques for PAH exposure. There was a clear difference between PAH profiles in sediments and eel. Mainly two- and three-ring PAHs were detected in eel, whereas four-ring PAHs predominated in the sediments. Because PAH bioaccumulation was highest in eel from the reference sites, tissue levels of the parental PAH are probably not the most accurate monitor of PAH exposure in fish. An elevated excretion of 1-OH pyrene (determined by synchronous scan fluorescence) was observed in the bile of fish from three of the four polluted sites, indicating that this parameter may be used as a biomarker for PAH exposure. A significant increase in PAH-DNA adduct levels was observed in the liver of eel from all polluted sites. Therefore, this parameter seems to be a sensitive biomarker for exposure to mutagenic and carcinogenic PAHs.

• OSTI ID: 7273339
• Journal Information: Environmental Toxicology and Chemistry; (United States), Journal Name: Environmental Toxicology and Chemistry; (United States) Vol. 13:6; ISSN ETOCDK; ISSN 0730-7268
• Country of Publication: United States
• Language: English

Related Subjects

54 ENVIRONMENTAL SCIENCES
540320* -- Environment
Aquatic-- Chemicals Monitoring & Transport-- (1990-)
560300 -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADDUCTS
ANIMALS
AQUATIC ORGANISMS
AROMATICS
BIOLOGICAL ACCUMULATION
BIOLOGICAL EFFECTS
BIOLOGICAL MARKERS
CONTAMINATION
DNA ADDUCTS
EEL
FISHES
GENETIC EFFECTS
HYDROCARBONS
METABOLISM
ORGANIC COMPOUNDS
POLLUTION
POLYCYCLIC AROMATIC HYDROCARBONS
SEDIMENTS
SENSITIVITY
VERTEBRATES
WATER POLLUTION