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Pulse radiolysis and ESR studies of the electron-affinic properties of nitroheterocyclic radiosensitizers. [Electron beams]

Journal Article · · Radiat. Res.; (United States)
DOI:https://doi.org/10.2307/3574452· OSTI ID:7267335
;
An attempt has been made to correlate some aspects of the radiation chemistry of various nitroheterocyclic compounds as cellular radiosensitizers with their electron-affinities as measured polarographically by their half-wave redox potentials. The nitroheterocyclic compounds accept electrons from a variety of radicals and radical anions formed in simple biological target molecules following H, OH, and e/sub aq/-attack. The resulting nitroheterocyclic radical anions can themselves donate electrons to both oxygen and quinones as electron acceptors. The rate constants and efficiencies of these electron-transfer reactions, many of which are diffusion-controlled, have been determined by pulse radiolysis, and the effect of nitroheterocyclic electron-affinity is discussed. The electron-affinities of the nitroheterocyclic compounds, as measured by the half-wave redox potentials, correlate well with the electron spin densities on the nitro groups of their radical anions, as determined by ESR. The spin density, which decreases linearly with increasing nitroheterocyclic redox potential, is also a useful measure of cellular radiosensitizing effectiveness.
Research Organization:
Atomic Energy of Canada Ltd., Pinawa, Manitoba
OSTI ID:
7267335
Journal Information:
Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 66:3; ISSN RAREA
Country of Publication:
United States
Language:
English

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Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400600* -- Radiation Chemistry
BEAMS
CHEMICAL RADIATION EFFECTS
CHEMICAL REACTION KINETICS
CHEMICAL REACTIONS
CHEMISTRY
DECOMPOSITION
DRUGS
ELECTRON BEAMS
ELECTRON SPIN RESONANCE
ELECTRON TRANSFER
HETEROCYCLIC COMPOUNDS
IRRADIATION
KINETICS
LEPTON BEAMS
MAGNETIC RESONANCE
ORGANIC COMPOUNDS
PARTICLE BEAMS
PULSED IRRADIATION
RADIATION CHEMISTRY
RADIATION EFFECTS
RADIOLYSIS
RADIOSENSITIZERS
REACTION KINETICS
REDOX POTENTIAL
RESONANCE
RESPONSE MODIFYING FACTORS