Clinical, morphologic, and cytogenetic characteristics of patients with lymphoid malignancies characterized by both t(14; 18)(q32; q21) and t(8; 14)(q24; q32) or t(8; 22)(q24; q11)
- Univ. of Chicago, IL (United States)
Six patients with an aggressive leukemia/lymphoma disorder had a t(14;18) as well as either a t(8;14) (three patients) or a t(8;22) (three patients). Leukemia cells from all three patients with the t(8;22) had a mature B cell phenotype (Smlg{sup +} and TdT{sup {minus}}), whereas two of three patients with the t(8;14) had a pre-B phenotype and were Smlg{sup {minus}}. None of the patients with the t(8;22) had a prior history of follicular lymphoma, whereas two of the three patients with the t(8;14) had had a follicular lymphoma. The clinical, cytogenetic, and morphologic characteristics of these six patients along with the eight previously reported cases with both the t(14;18) and the t(8;14), the t(8;22) or the t(2;8) are discussed.
- DOE Contract Number:
- FG02-86ER60408
- OSTI ID:
- 7260715
- Journal Information:
- Genes, Chromosomes and Cancer; (United States), Journal Name: Genes, Chromosomes and Cancer; (United States) Vol. 2; ISSN 1045-2257; ISSN GCCAE
- Country of Publication:
- United States
- Language:
- English
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