Behavior and biochemical analysis of phencyclidine

Thesis/Dissertation · Fri Jan 01 00:00:00 EST 1988

OSTI ID:7255520

McCann, D J

The objectives of this research were: (1) to develop the radial maze as a tool for the study of phencyclidine (PCP) and related drugs; (2) to evaluate verapamil and colonidine, two proposed treatments for PCP intoxication, as potential antagonists of PCP in the radial maze; and (3) to evaluate the functionality of two distinct types of PCP binding sites as receptors by comparing, for a series of drugs, activity in competitive binding experiments with behavioral activity. The radial maze proved to be a useful tool for the study of PCP and related drugs. With training, rats became highly efficient at obtaining the 8 food pellets placed in the maze. However, PCP and related drugs disrupted this performance, causing numerous reentries into previously visited arms. Results of correlation analyses comparing rank-order affinities with rank-order potencies of (+)SKF-10,047 (the prototypical sigma-opioid agonist), PCP, and several PCP analogs support the involvement of ({sup 3}H)-1-(2-thienyl)cyclohexyl piperidine binding sites (TCP sites) in mediating both the discriminative stimulus properties of PCP and disruption of performance in a 4-arm radial maze.

• Research Organization: State Univ. of New York, Buffalo, NY (USA)
• OSTI ID: 7255520
• Resource Relation: Other Information: Thesis (Ph. D.)
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
ANTIHYPERTENSIVE AGENTS
BIOCHEMICAL REACTION KINETICS
PIPERIDINES
BIOCHEMISTRY
VASODILATORS
CPB
RATS
RECEPTORS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
AMINES
ANIMALS
AZINES
CARDIOVASCULAR AGENTS
CHEMISTRY
DRUGS
HETEROCYCLIC COMPOUNDS
HYDROGEN COMPOUNDS
ISOTOPE APPLICATIONS
KINETICS
MAMMALS
MEMBRANE PROTEINS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PROTEINS
PYRIDINES
REACTION KINETICS
RODENTS
VERTEBRATES
550201* - Biochemistry- Tracer Techniques