Effect of ultraviolet radiation on the energy metabolism of the corneal epithelium of the rabbit. Final report
Technical Report
·
OSTI ID:7254620
The present research was directed at quantifying possible alterations in corneal epithelial metabolic activity secondary to in-vivo exposure to ultraviolet radiation (UVR). Microfluorometric energy metabolite assays on microgram (ug) sized, freeze-dried tissue samples were used as an in vitro means of assessing overall metabolic activity in the epithelium of control rabbit corneas and in the epithelium of UVR-exposed rabbit corneas 2 min after discontinuation of exposure. The specific assays were for glucose, glycogen, adenosine triphosphate (ATP), and phosphocreatine (PCr). The radiant exposures were kept constant at 0.05 J cm-2 for all UVR wavelengths utilized (290, 300, 310 and 360 nm). Experimental UVR exposure conditions served to increase epithelial glucose and glycogen concentrations. Although the epithelial ATP concentrations were unchanged, the epithelial PCr concentrations (a high energy phosphate bond reservoir) decreased as a result of UVR exposure. Overall, the data demonstrate a decrease in corneal epithelial metabolic activity, which may be wavelength-dependent, as a result of UVR exposure. It is suggested that immediate metabolic stress can be responsible for the pattern of epithelial cell loss seen in photokeratitis.
- Research Organization:
- Army Aeromedical Research Lab., Fort Rucker, AL (USA)
- OSTI ID:
- 7254620
- Report Number(s):
- AD-A-214558/9/XAB; USAARL--89-26
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560120* -- Radiation Effects on Biochemicals
Cells
& Tissue Culture
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALDEHYDES
AMINO ACIDS
ANIMAL TISSUES
ANIMALS
ATP
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
CARBOHYDRATES
CARBOXYLIC ACIDS
CELL CONSTITUENTS
CORNEA
DOCUMENT TYPES
ELECTROMAGNETIC RADIATION
EPITHELIUM
EYES
FACE
GLUCOSE
GLYCOGEN
HEAD
HEXOSES
IN VITRO
IN VIVO
LOSSES
MAMMALS
METABOLISM
METABOLITES
MITOCHONDRIA
MONOSACCHARIDES
NUCLEOTIDES
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANOIDS
ORGANS
PHOSPHOCREATINE
POLYSACCHARIDES
PROGRESS REPORT
RABBITS
RADIATION EFFECTS
RADIATIONS
SACCHARIDES
SAMPLING
SENSE ORGANS
TISSUE CULTURES
TISSUES
ULTRAVIOLET RADIATION
VERTEBRATES
Cells
& Tissue Culture
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALDEHYDES
AMINO ACIDS
ANIMAL TISSUES
ANIMALS
ATP
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
CARBOHYDRATES
CARBOXYLIC ACIDS
CELL CONSTITUENTS
CORNEA
DOCUMENT TYPES
ELECTROMAGNETIC RADIATION
EPITHELIUM
EYES
FACE
GLUCOSE
GLYCOGEN
HEAD
HEXOSES
IN VITRO
IN VIVO
LOSSES
MAMMALS
METABOLISM
METABOLITES
MITOCHONDRIA
MONOSACCHARIDES
NUCLEOTIDES
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANOIDS
ORGANS
PHOSPHOCREATINE
POLYSACCHARIDES
PROGRESS REPORT
RABBITS
RADIATION EFFECTS
RADIATIONS
SACCHARIDES
SAMPLING
SENSE ORGANS
TISSUE CULTURES
TISSUES
ULTRAVIOLET RADIATION
VERTEBRATES