Swiveling and decatenation of replicating simian virus 40 genomes in vivo
Journal Article
·
· Mol. Cell. Biol.; (United States)
The authors found that type II topoisomerase inhibitors have two effects on replicating simian virus 40 genomes in vivo: production of catenated dimers and slowed replication of the last 5% of the genome. This suggests that type II topoisomerase simultaneously decatenates and facilitates replication fork movement at this stage of DNA replication. On the basis of this observation, a detailed model is proposed for the roles of topoisomerases I and II in simian virus 40 DNA replication.
- Research Organization:
- Div. of Radiobiology, Dept. of Radiology, The Ohio State Univ., Columbus, OH 43210 (US)
- OSTI ID:
- 7253616
- Journal Information:
- Mol. Cell. Biol.; (United States), Journal Name: Mol. Cell. Biol.; (United States) Vol. 8:2; ISSN MCEBD
- Country of Publication:
- United States
- Language:
- English
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