Measurement of deuterium kinetic isotope effects in organic and biochemical reactions by natural abundance deuterium NMR spectroscopy

Journal Article · Wed Oct 15 00:00:00 EDT 1986 · J. Am. Chem. Soc.; (United States)

DOI:https://doi.org/10.1021/ja00281a005· OSTI ID:7251440

Pascal, Jr, R A; Baum, M W; Wagner, C K; Rodgers, L R; Huang, D S

Natural abundance deuterium NMR spectroscopy is a powerful and convenient tool for the estimation of deuterium kinetic isotope effects in organic reactions, obviating in many cases the preparation of isotopically enriched reactants for such measurements. Determination of the primary or secondary kinetic isotope effects for a broad variety of reaction types are described to illustrate this technique.

• Research Organization: Princeton Univ., NJ
• OSTI ID: 7251440
• Journal Information: J. Am. Chem. Soc.; (United States), Journal Name: J. Am. Chem. Soc.; (United States) Vol. 108:21; ISSN JACSA
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
400102 -- Chemical & Spectral Procedures
400202* -- Isotope Effects
Isotope Exchange
& Isotope Separation
BIOCHEMICAL REACTION KINETICS
CHEMICAL REACTION KINETICS
CHEMICAL REACTIONS
DATA
DEUTERIUM
DEUTERIUM COMPOUNDS
EXPERIMENTAL DATA
HYDROGEN COMPOUNDS
HYDROGEN ISOTOPES
INFORMATION
ISOTOPE EFFECTS
ISOTOPES
KINETICS
LIGHT NUCLEI
MAGNETIC RESONANCE
NMR SPECTRA
NUCLEAR MAGNETIC RESONANCE
NUCLEI
NUMERICAL DATA
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
REACTION KINETICS
RESONANCE
SPECTRA
STABLE ISOTOPES