Metabolic activation and DNA adducts of dinitropyrenes. Research report, 1 January 1984-31 December 1985
The study explored the sequence of reactions through which nitrated pyrenes, important mutagenic and potentially carcinogenic components of diesel exhaust, are converted metabolically within bacterial and mammalian cells into reactive forms that damage DNA. Results indicate that (1) factors in addition to nitroreduction were involved in the metabolic activation of dinitropyrene, (2) differences exist among the nitropyrene compounds tested in the mechanism of nitroreduction, (3) reduction to 1-nitrosopyrene is the limiting step in the metabolic activation of 1-nitropyrene, while subsequent esterification of the reduced intermediates is critical for the activation of the dinitropyrenes, (4) the extent of DNA binding of the different compounds was correlated with the extent of their nitroreduction, and (5) anaerobic intestinal microflora play an important role in metabolizing orally administered nitropyrenes.
- Research Organization:
- Arkansas Univ. for Medical Sciences, Little Rock (USA). Dept. of Biochemistry
- OSTI ID:
- 7248379
- Report Number(s):
- PB-86-246287/XAB
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
Atmospheric-- Chemicals Monitoring & Transport-- (-1989)
54 ENVIRONMENTAL SCIENCES
560300 -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADDUCTS
AROMATICS
CARCINOGENS
DIESEL FUELS
DNA ADDUCTS
EXHAUST GASES
FLUIDS
GASEOUS WASTES
GASES
HYDROCARBONS
METABOLISM
ORGANIC COMPOUNDS
PETROLEUM PRODUCTS
POLYCYCLIC AROMATIC HYDROCARBONS
WASTES