Glucagon releases Ca/sup 2 +/ from a FCCP-sensitive pool
Conference
·
· Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)
OSTI ID:7246460
The effects of physiological levels of glucagon on Ca/sup 2 +/ efflux were examined in the perfused rat liver. Two methods were used to estimate Ca/sup 2 +/ efflux: (1) prior labeling of the Ca/sup 2 +/ pools with /sup 45/Ca/sup 2 +/, and (2) measurement of perfusate Ca/sup 2 +/ with atomic absorption. According to both methods, glucagon administration at the physiological level evoked Ca/sup 2 +/ release. In order to identify the hormone-sensitive Ca/sup 2 +/ pool, a method employed by several laboratories was used. In this method, mitochondrial Ca/sup 2 +/ is released by FCCP, (carbonyl-cyanide 4 (trifluoro/methoxy) phenylhydrazone), a mitochondrial uncoupler. The effect of hormones on Ca/sup 2 +/ release after such uncoupler administration is measured. A decreased release is taken as an indication that the pool is entirely or partially mitochondrial. FCCP released 90 +/- 29 nmoles Ca/sup 2 +//gr wet liver. Glucagon (5 x 10/sup -9/ M) released 107 +/- 45 nmoles Ca/sup 2 +//gr wet liver before and 26 +/- 9 nmoles Ca/sup 2 +//gr wet liver after FCCP. These data indicate that glucagon releases Ca/sup 2 +/ mostly from the mitochondria.
- Research Organization:
- Univ. of Texas Medical School, Houston
- OSTI ID:
- 7246460
- Report Number(s):
- CONF-8606151-
- Conference Information:
- Journal Name: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States) Journal Volume: 45:6
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ABSORPTION SPECTRA
ALKALINE EARTH ISOTOPES
ALKALINE EARTH METAL COMPOUNDS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BODY
CALCIUM 45
CALCIUM COMPOUNDS
CALCIUM ISOTOPES
CATIONS
CELL CONSTITUENTS
CHARGED PARTICLES
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
EVEN-ODD NUCLEI
GLANDS
GLUCAGON
HORMONES
INTERMEDIATE MASS NUCLEI
IONS
ISOTOPE APPLICATIONS
ISOTOPES
LIVER
MAMMALS
MEMBRANE TRANSPORT
MITOCHONDRIA
NUCLEI
ORGANIC COMPOUNDS
ORGANOIDS
ORGANS
PEPTIDE HORMONES
PEPTIDES
PERFUSED ORGANS
POLYPEPTIDES
PROTEINS
RADIOISOTOPES
RATS
RODENTS
SPECTRA
TRACER TECHNIQUES
VERTEBRATES
59 BASIC BIOLOGICAL SCIENCES
ABSORPTION SPECTRA
ALKALINE EARTH ISOTOPES
ALKALINE EARTH METAL COMPOUNDS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BODY
CALCIUM 45
CALCIUM COMPOUNDS
CALCIUM ISOTOPES
CATIONS
CELL CONSTITUENTS
CHARGED PARTICLES
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
EVEN-ODD NUCLEI
GLANDS
GLUCAGON
HORMONES
INTERMEDIATE MASS NUCLEI
IONS
ISOTOPE APPLICATIONS
ISOTOPES
LIVER
MAMMALS
MEMBRANE TRANSPORT
MITOCHONDRIA
NUCLEI
ORGANIC COMPOUNDS
ORGANOIDS
ORGANS
PEPTIDE HORMONES
PEPTIDES
PERFUSED ORGANS
POLYPEPTIDES
PROTEINS
RADIOISOTOPES
RATS
RODENTS
SPECTRA
TRACER TECHNIQUES
VERTEBRATES