N-hydroxy-2-acetylaminofluorene as effective inhibitor of aldehyde oxidase
Journal Article
·
· Biochem. Biophys. Res. Commun.; (United States)
N-Hydroxy-2-acetylaminofluorene has been found to be an effective inhibitor of aldehyde oxidase. At concentrations of 1 x 10/sup -6/M and 1 x 10/sup -5/M, 38% and 88% inhibition was observed on the oxidase activity towards N/sup 1/-methylnicotinamide. The inhibition was of noncompetitive type and had a Ki value of 4.4 x 10/sup -6/. In contrast, little inhibition of the enzyme was observed with 2-aminofluorene, 2-acetylaminofluorene and acetohydroxamic acid even at a concentration of 1 x 10/sup -4/M.
- Research Organization:
- Hiroshima Univ. School of Medicine, Japan
- OSTI ID:
- 7245158
- Journal Information:
- Biochem. Biophys. Res. Commun.; (United States), Journal Name: Biochem. Biophys. Res. Commun.; (United States) Vol. 138:1; ISSN BBRCA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550200 -- Biochemistry
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACETYLAMINOFLUORENES
ALDEHYDES
AMIDES
AMINES
AZINES
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
DATA
ENZYME ACTIVITY
ENZYME INHIBITORS
ENZYMES
EXPERIMENTAL DATA
HETEROCYCLIC COMPOUNDS
HYDROXAMIC ACIDS
HYDROXY COMPOUNDS
INFORMATION
INHIBITION
KINETICS
NICOTINAMIDE
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OXIDOREDUCTASES
PYRIDINES
REACTION KINETICS
VITAMIN B GROUP
VITAMINS
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACETYLAMINOFLUORENES
ALDEHYDES
AMIDES
AMINES
AZINES
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
DATA
ENZYME ACTIVITY
ENZYME INHIBITORS
ENZYMES
EXPERIMENTAL DATA
HETEROCYCLIC COMPOUNDS
HYDROXAMIC ACIDS
HYDROXY COMPOUNDS
INFORMATION
INHIBITION
KINETICS
NICOTINAMIDE
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OXIDOREDUCTASES
PYRIDINES
REACTION KINETICS
VITAMIN B GROUP
VITAMINS