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Microwave-induced cataracts of the eye lens. strategies for modeling and prevention in vitro and in vivo. Annual summary report, 1 June 1982-30 May 1983

Technical Report ·
OSTI ID:7245058
A unique system was developed for study of the development of microwave-induced cortical cataracts of the eye lens, using as a model system the rat lens incubated a in circulating tissue culture medium at controlled temperature, while being exposed to microwave irradiation. Although in unirradiated controls no cataracts occur, levels of microwave irradiation were used at which characteristic cataractous opacities with associated globular degeneration occur. Studies of microwaves will continue, using the following techniques: 1) scanning and 2) transmission electron microscopy, 3) high-voltage electron microscopy, (a powerful technique for detecting alterations in cytoskeleton structure), 4) cryological electron-stimulated detection of x rays (EDX) (a technique for examining the ionic composition of fresh tissue), and (5) biochemistry. The author hopes to elucidate the mechanism of the previously unreported unique effects of high energy pulsed microwaves, which appear to be related to thermoacoutic transduction. Studies to date have established several cataractogenic doses but not looked at the minimum effective dose, and have noted several features of the irradiated lens apparently related to the power temperature and duration of the irradiation and to the mode of delivery (constant amplitude (CW) or high energy pulsed (Pu)).
Research Organization:
University of Western Ontario, London (Canada). Dept. of Biochemistry
OSTI ID:
7245058
Report Number(s):
AD-A-171458/3/XAB
Country of Publication:
United States
Language:
English

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Related Subjects

560400* -- Other Environmental Pollutant Effects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
CATARACTS
CRYSTALLINE LENS
DISEASES
ELECTROMAGNETIC RADIATION
EYES
FACE
HEAD
HIGH TEMPERATURE
MAMMALS
MICROWAVE RADIATION
ORGANS
PULSES
RADIATION EFFECTS
RADIATIONS
RATS
RODENTS
SENSE ORGANS
SENSE ORGANS DISEASES
VERTEBRATES
VITAMINS