Radiopharmaceuticals for thrombus detection
- Temple Univ. School of Medicine and Hospital, Philadelphia, PA (USA)
Most of the components of the thrombotic and fibrinolytic systems have at some time been evaluated as a means of carrying a radiolabel specifically to thrombi, although very few have been promising enough to emerge from investigational status to routine clinical use. New approaches are being explored, including improved methods of labeling platelets, chemically modified forms of previously tested plasma proteins, and new biomolecules, including monoclonal antibodies specific for fibrin and platelets. The current goal is to find one or more radiotracers that bind specifically and rapidly to thrombi, and that also have a rapid blood disappearance rate, permitting a clear diagnosis within a few hours after injection. Because this test may be needed to assess the course of therapy in an anticoagulated patient, the ideal radiopharmaceutical should be able to locate thrombi without interference by anticoagulants. Until a suitable thrombus-specific radiopharmaceutical becomes generally available, many hospitals will continue to attempt to make a diagnosis with nonspecific radiopharmaceuticals that can at best provide blood pool images to indicate filling defects. Several of the new approaches seem likely to provide the radiopharmaceutical sought, although clinical trials are at an early stage.137 references.
- OSTI ID:
- 7244524
- Journal Information:
- Seminars in Nuclear Medicine; (USA), Journal Name: Seminars in Nuclear Medicine; (USA) Vol. 20:1; ISSN 0001-2998; ISSN SMNMA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
ACCURACY
ANIMALS
ANTIBODIES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD COAGULATION FACTORS
BLOOD PLATELETS
BODY FLUIDS
CARDIOVASCULAR DISEASES
COAGULANTS
DIAGNOSIS
DISEASES
DOCUMENT TYPES
DRUGS
FIBRINOGEN
GLOBULINS
HEMATOLOGIC AGENTS
HEMOSTATICS
LABELLED COMPOUNDS
MAMMALS
MAN
MATERIALS
MONOCLONAL ANTIBODIES
ORGANIC COMPOUNDS
PRIMATES
PROTEINS
RADIOPHARMACEUTICALS
REVIEWS
THROMBOSIS
VASCULAR DISEASES
VERTEBRATES