sup 13 C and sup 31 P NMR (Nuclear Magnetic Resonance) studies of prostate tumor metabolism
The current research on prostate cancer by NMR spectroscopy and microscopy will most significantly contribute to tumor diagnosis and characterization only if sound biochemical models of tumor metabolism are established and tested. Prior searches focused on universal markers of malignancy, have to date, revealed no universal markers by any method. It is unlikely that NMRS will succeed where other methods have failed, however, NMR spectroscopy does provide a non-invasive means to analyze multiple compounds simultaneously in vivo. In order to fully evaluate the ability of NMRS to differentiate non-malignant from malignant tissues it is necessary to determine sufficient multiple parameters from specific, well-diagnosed, histological tumor types that, in comparison to normal tissue and non-neoplastic, non-normal pathologies from which the given neoplasm must be differentiated, one has enough degrees of freedom to make a mathematically and statistically significant determination. Confounding factors may consist of tumor heterogeneity arising from regional variations in differentiation, ischemia, necrosis, hemorrhage, inflammation and the presence of intermingled normal tissue. One related aspect of our work is the development of {l brace}{sup 13}C{r brace}-{sup 1}H metabolic imaging of {sup 13}C for metabolic characterization, with enhanced spatial localization (46). This should markedly extend the range of potential clinical NMR uses because the spatial variation in prostate metabolism may prove to be just as important in tumor diagnoses as bulk (volume-averaged) properties themselves. It is our hope that NMRS and spectroscopic imaging will reveal a sound correlation between prostate metabolism and tumor properties that will be clinically straightforward and useful for diagnosis.
- Research Organization:
- Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
- Sponsoring Organization:
- ACS; DOE/ER; DOHHS; VETAD
- DOE Contract Number:
- W-7405-ENG-36
- OSTI ID:
- 7244519
- Report Number(s):
- LA-UR-89-3519; CONF-8904327-1; ON: DE90002401; TRN: 90-008730
- Resource Relation:
- Conference: 21. annual Wayne State cancer symposium, Detroit, MI (USA), 13-14 Apr 1989
- Country of Publication:
- United States
- Language:
- English
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COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC USES
NMR IMAGING
IMAGE PROCESSING
PROSTATE
ADENOMAS
CARBON 13
PATHOLOGICAL CHANGES
PHOSPHORUS 31
TECHNOLOGY ASSESSMENT
BODY
CARBON ISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
EVEN-ODD NUCLEI
GLANDS
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LIGHT NUCLEI
MALE GENITALS
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NUCLEI
ODD-EVEN NUCLEI
ORGANS
PHOSPHORUS ISOTOPES
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STABLE ISOTOPES
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